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SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.

Publication ,  Journal Article
Sungnak, W; Huang, N; Bécavin, C; Berg, M; Queen, R; Litvinukova, M; Talavera-López, C; Maatz, H; Reichart, D; Sampaziotis, F; Worlock, KB ...
Published in: Nat Med
May 2020
Published version (DOI) Link to item

We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.

Duke Scholars

Purushothama Rao Tata
Author Purushothama Rao Tata Cell Biology
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Published In

Nat Med

DOI

10.1038/s41591-020-0868-6

EISSN

1546-170X

Publication Date

May 2020

Volume

26

Issue

5

Start / End Page

681 / 687

Location

United States

Related Subject Headings

  • Immunology
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences
 

Citation

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Sungnak, W., Huang, N., Bécavin, C., Berg, M., Queen, R., Litvinukova, M., … HCA Lung Biological Network, . (2020). SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med, 26(5), 681–687. https://doi.org/10.1038/s41591-020-0868-6
Sungnak, Waradon, Ni Huang, Christophe Bécavin, Marijn Berg, Rachel Queen, Monika Litvinukova, Carlos Talavera-López, et al. “SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.” Nat Med 26, no. 5 (May 2020): 681–87. https://doi.org/10.1038/s41591-020-0868-6.
Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, et al. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med. 2020 May;26(5):681–7.
Sungnak, Waradon, et al. “SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.” Nat Med, vol. 26, no. 5, May 2020, pp. 681–87. Pubmed, doi:10.1038/s41591-020-0868-6.
Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, Talavera-López C, Maatz H, Reichart D, Sampaziotis F, Worlock KB, Yoshida M, Barnes JL, HCA Lung Biological Network. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med. 2020 May;26(5):681–687.

Published In

Nat Med

DOI

10.1038/s41591-020-0868-6

EISSN

1546-170X

Publication Date

May 2020

Volume

26

Issue

5

Start / End Page

681 / 687

Location

United States

Related Subject Headings

  • Immunology
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences