Copper-Catalyzed 1,2-Aminocyanation of Unactivated Alkenes via Cyano Migration.
Journal Article (Journal Article)
A copper-catalyzed aminocyanation of alkenes has been achieved through distal cyano migration using O -benzoylhydroxylamines and N -fluorobenzenesulfonimides. This method offers a rapid approach to generate diverse β-amino and β-sulfonimido nitriles. These reactions feature mild conditions, tolerance of sensitive functional groups, and excellent regioselectivity. Mechanistic studies suggest that these transformations are initiated by a copper-catalyzed amination step followed by a cyano migration step.
- Kwon, Y; Wang, Q
- June 2020
Volume / Issue
- 22 / 11
Start / End Page
- 4141 - 4145
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)