Copper-Catalyzed 1,2-Aminocyanation of Unactivated Alkenes via Cyano Migration.

Journal Article (Journal Article)

A copper-catalyzed aminocyanation of alkenes has been achieved through distal cyano migration using O -benzoylhydroxylamines and N -fluorobenzenesulfonimides. This method offers a rapid approach to generate diverse β-amino and β-sulfonimido nitriles. These reactions feature mild conditions, tolerance of sensitive functional groups, and excellent regioselectivity. Mechanistic studies suggest that these transformations are initiated by a copper-catalyzed amination step followed by a cyano migration step.

Full Text

Duke Authors

Wang, Qiu

Cited Authors

Kwon, Y; Wang, Q

Published Date

June 2020

Published In

Organic Letters

Volume / Issue

22 / 11

Start / End Page

4141 - 4145

PubMed ID

32383382

Pubmed Central ID

PMC7505134

Electronic International Standard Serial Number (EISSN)

1523-7052

International Standard Serial Number (ISSN)

1523-7060

Digital Object Identifier (DOI)

10.1021/acs.orglett.0c01217

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