Copper-Catalyzed 1,2-Aminocyanation of Unactivated Alkenes via Cyano Migration.

Published

Journal Article

A copper-catalyzed aminocyanation of alkenes has been achieved through distal cyano migration using O-benzoylhydroxylamines and N-fluorobenzenesulfonimides. This method offers a rapid approach to generate diverse β-amino and β-sulfonimido nitriles. These reactions feature mild conditions, tolerance of sensitive functional groups, and excellent regioselectivity. Mechanistic studies suggest that these transformations are initiated by a copper-catalyzed amination step followed by a cyano migration step.

Full Text

Duke Authors

Cited Authors

  • Kwon, Y; Wang, Q

Published Date

  • June 2020

Published In

Volume / Issue

  • 22 / 11

Start / End Page

  • 4141 - 4145

PubMed ID

  • 32383382

Pubmed Central ID

  • 32383382

Electronic International Standard Serial Number (EISSN)

  • 1523-7052

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/acs.orglett.0c01217

Language

  • eng