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Esophageal Baseline Impedance From High-resolution Impedance Manometry Correlates With Mean Nocturnal Baseline Impedance From pH-impedance Monitoring.

Publication ,  Journal Article
Horton, A; Sullivan, B; Charles, K; McIntosh, T; Davis, A; Gellad, Z; Shimpi, R; Gyawali, CP; Patel, A
Published in: J Neurogastroenterol Motil
September 30, 2020

BACKGROUND/AIMS: Esophageal baseline impedance (BI) can be extracted from pH-impedance tracings as mean nocturnal baseline impedance (MNBI), and from high-resolution impedance manometry (HRIM), but it is unknown if values are similar between acquisition methods across HRIM manufacturers. We aim to assess correlations between MNBI and BI from HRIM (BI-HRIM) from 2 HRIM manufacturers in the setting of physiologic acid exposure time (AET). METHODS: HRIM and pH-impedance monitoring demonstrating physiologic AET (< 4%) off proton pump inhibitors were required. BI-HRIM was extracted as the average from 5 cm and 10 cm above the lower esophageal sphincter. Distal BI-HRIM (DBI-HRIM) was also extracted from the most distal channel (Medtronic studies). MNBI was extracted from 6 channels. Concordance between BI-HRIM across manufacturers with MNBI was analyzed. RESULTS: Thirty-six patients met the inclusion criteria (59.6 ± 1.7 years; 22% female; body mass index 30.5 ± 0.7; AET 1.6 ± 0.2%). Although MNBI was similar at all channels (P ≥ 0.18), Diversatek BI-HRIM was lower than Medtronic BI-HRIM (P = 0.003). Overall, BI-HRIM correlated with MNBI at corresponding recording sites, 7 cm and 9 cm (P < 0.05), but not at other sites (P ≥ 0.19). Pearson's correlations > 0.5 were seen at MNBI at 7 cm for both systems, and at 9 cm for Medtronic. DBI-HRIM correlated with MNBI at 3 cm and 5 cm (P < 0.03), but not at other locations (P > 0.1). CONCLUSIONS: While numeric differences exist between manufacturers, BI-HRIM correlates with MNBI from corresponding channels in patients with physiologic AET. Comparison with AET elevation is needed to determine correlations between pathologic MNBI with BI-HRIM across manufacturers. The optimal HRIM channels from which BI values should be extracted also warrants further study.

Duke Scholars

Published In

J Neurogastroenterol Motil

DOI

ISSN

2093-0879

Publication Date

September 30, 2020

Volume

26

Issue

4

Start / End Page

455 / 462

Location

Korea (South)

Related Subject Headings

  • 3202 Clinical sciences
  • 1103 Clinical Sciences
  • 1101 Medical Biochemistry and Metabolomics
 

Citation

APA
Chicago
ICMJE
MLA
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Horton, A., Sullivan, B., Charles, K., McIntosh, T., Davis, A., Gellad, Z., … Patel, A. (2020). Esophageal Baseline Impedance From High-resolution Impedance Manometry Correlates With Mean Nocturnal Baseline Impedance From pH-impedance Monitoring. J Neurogastroenterol Motil, 26(4), 455–462. https://doi.org/10.5056/jnm19142
Horton, Anthony, Brian Sullivan, Katie Charles, Thasha McIntosh, Andrea Davis, Ziad Gellad, Rahul Shimpi, C Prakash Gyawali, and Amit Patel. “Esophageal Baseline Impedance From High-resolution Impedance Manometry Correlates With Mean Nocturnal Baseline Impedance From pH-impedance Monitoring.J Neurogastroenterol Motil 26, no. 4 (September 30, 2020): 455–62. https://doi.org/10.5056/jnm19142.
Horton A, Sullivan B, Charles K, McIntosh T, Davis A, Gellad Z, et al. Esophageal Baseline Impedance From High-resolution Impedance Manometry Correlates With Mean Nocturnal Baseline Impedance From pH-impedance Monitoring. J Neurogastroenterol Motil. 2020 Sep 30;26(4):455–62.
Horton, Anthony, et al. “Esophageal Baseline Impedance From High-resolution Impedance Manometry Correlates With Mean Nocturnal Baseline Impedance From pH-impedance Monitoring.J Neurogastroenterol Motil, vol. 26, no. 4, Sept. 2020, pp. 455–62. Pubmed, doi:10.5056/jnm19142.
Horton A, Sullivan B, Charles K, McIntosh T, Davis A, Gellad Z, Shimpi R, Gyawali CP, Patel A. Esophageal Baseline Impedance From High-resolution Impedance Manometry Correlates With Mean Nocturnal Baseline Impedance From pH-impedance Monitoring. J Neurogastroenterol Motil. 2020 Sep 30;26(4):455–462.

Published In

J Neurogastroenterol Motil

DOI

ISSN

2093-0879

Publication Date

September 30, 2020

Volume

26

Issue

4

Start / End Page

455 / 462

Location

Korea (South)

Related Subject Headings

  • 3202 Clinical sciences
  • 1103 Clinical Sciences
  • 1101 Medical Biochemistry and Metabolomics