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Flavonoid intake and its association with atrial fibrillation.

Publication ,  Journal Article
Bondonno, NP; Murray, K; Bondonno, CP; Lewis, JR; Croft, KD; Kyrø, C; Gislason, G; Tjønneland, A; Scalbert, A; Cassidy, A; Piccini, JP ...
Published in: Clin Nutr
December 2020

BACKGROUND & AIMS: Primary prevention of atrial fibrillation (AF) through behavioural and dietary modification is a critically important and unmet need. Flavonoids are bioactive dietary compounds with promising cardiovascular health benefits. Our aim was to investigate the association between flavonoid intake and clinically apparent AF. METHODS: Baseline data from 55 613 participants of the Danish Diet, Cancer and Health Study, without AF, recruited between 1993 and 1997, were cross-linked with Danish nationwide registries. Total flavonoid and flavonoid subclass intakes were calculated from validated food frequency questionnaires using the Phenol-Explorer database. Associations between flavonoid intake and incident AF (first-time hospitalization or outpatient visit) were examined using restricted cubic splines based on Cox proportional hazards models. RESULTS: During a median [IQR] follow-up of 21 [18-22] years, 7291 participants were diagnosed with AF. Total flavonoid intake was not statistically significantly associated with risk of incident AF in the whole cohort. However, compared to the lowest quintile, a total flavonoid intake of 1000 mg/day was associated with a lower risk of AF in smokers [0.86 (0.77, 0.96)] but not in non-smokers [0.96 (0.88, 1.06)], and a lower risk of AF in high alcohol consumers [>20 g/d: 0.84 (0.75, 0.95)] but not in low-to-moderate alcohol consumers [<20 g/d: 0.97 (0.89, 1.07)]. CONCLUSION: Intake of flavonoids was not significantly associated with a lower risk of incident AF. However, higher intakes of flavonoids may be beneficial for those at a higher risk of developing AF.

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Published In

Clin Nutr

DOI

EISSN

1532-1983

Publication Date

December 2020

Volume

39

Issue

12

Start / End Page

3821 / 3828

Location

England

Related Subject Headings

  • Registries
  • Proportional Hazards Models
  • Nutrition & Dietetics
  • Middle Aged
  • Male
  • Incidence
  • Humans
  • Heart Disease Risk Factors
  • Health Surveys
  • Flavonoids
 

Citation

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Chicago
ICMJE
MLA
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Bondonno, N. P., Murray, K., Bondonno, C. P., Lewis, J. R., Croft, K. D., Kyrø, C., … Dalgaard, F. (2020). Flavonoid intake and its association with atrial fibrillation. Clin Nutr, 39(12), 3821–3828. https://doi.org/10.1016/j.clnu.2020.04.025
Bondonno, Nicola P., Kevin Murray, Catherine P. Bondonno, Joshua R. Lewis, Kevin D. Croft, Cecilie Kyrø, Gunnar Gislason, et al. “Flavonoid intake and its association with atrial fibrillation.Clin Nutr 39, no. 12 (December 2020): 3821–28. https://doi.org/10.1016/j.clnu.2020.04.025.
Bondonno NP, Murray K, Bondonno CP, Lewis JR, Croft KD, Kyrø C, et al. Flavonoid intake and its association with atrial fibrillation. Clin Nutr. 2020 Dec;39(12):3821–8.
Bondonno, Nicola P., et al. “Flavonoid intake and its association with atrial fibrillation.Clin Nutr, vol. 39, no. 12, Dec. 2020, pp. 3821–28. Pubmed, doi:10.1016/j.clnu.2020.04.025.
Bondonno NP, Murray K, Bondonno CP, Lewis JR, Croft KD, Kyrø C, Gislason G, Tjønneland A, Scalbert A, Cassidy A, Piccini JP, Overvad K, Hodgson JM, Dalgaard F. Flavonoid intake and its association with atrial fibrillation. Clin Nutr. 2020 Dec;39(12):3821–3828.
Journal cover image

Published In

Clin Nutr

DOI

EISSN

1532-1983

Publication Date

December 2020

Volume

39

Issue

12

Start / End Page

3821 / 3828

Location

England

Related Subject Headings

  • Registries
  • Proportional Hazards Models
  • Nutrition & Dietetics
  • Middle Aged
  • Male
  • Incidence
  • Humans
  • Heart Disease Risk Factors
  • Health Surveys
  • Flavonoids