Benefits of Optimizing Heart Failure Medication Dosage

Journal Article (Journal Article)

Heart failure is the leading cause of hospitalizations and readmissions. Guideline-directed medical therapy is the cornerstone to improving outcomes, but less than 20% of patients with heart failure marked by reduced ejection fraction receive target doses. This report reviews the neurohormonal cascade that occurs in heart failure and the role of guideline-directed medical therapy based on the results of landmark trials. In addition, evidence-based strategies to up-titrate medications are described. Nurse practitioners are in an optimal situation to titrate guideline therapy with frequent follow-up and monitoring.

Full Text

Duke Authors

Cited Authors

  • Oliver-McNeil, S; Bowers, M; LaRue, SJ; Vader, J; DeVore, AD; Granger, BB

Published Date

  • July 1, 2020

Published In

Volume / Issue

  • 16 / 7

Start / End Page

  • 498 - 503

International Standard Serial Number (ISSN)

  • 1555-4155

Digital Object Identifier (DOI)

  • 10.1016/j.nurpra.2020.04.018

Citation Source

  • Scopus