Role of dendritic cell metabolic reprogramming in tumor immune evasion.

Journal Article (Journal Article;Review)

The dendritic cell (DC) is recognized as a vital mediator of anti-tumor immunity. More recent studies have also demonstrated the important role of DCs in the generation of effective responses to checkpoint inhibitor immunotherapy. Metabolic programming of DCs dictates their functionality and can determine which DCs become immunostimulatory versus those that develop a tolerized phenotype capable of actively suppressing effector T-cell responses to cancers. As a result, there is great interest in understanding what mechanisms have evolved in cancers to alter these metabolic pathways, thereby allowing for their continued progression and metastasis. The therapeutic strategies developed to reverse these processes of DC tolerization in the tumor microenvironment represent promising candidates for future testing in combination immunotherapy clinical trials.

Full Text

Duke Authors

Cited Authors

  • Plebanek, MP; Sturdivant, M; DeVito, NC; Hanks, BA

Published Date

  • June 26, 2020

Published In

Volume / Issue

  • 32 / 7

Start / End Page

  • 485 - 491

PubMed ID

  • 32449776

Pubmed Central ID

  • 32449776

Electronic International Standard Serial Number (EISSN)

  • 1460-2377

Digital Object Identifier (DOI)

  • 10.1093/intimm/dxaa036

Language

  • eng

Conference Location

  • England