Surgical Resection is Justifiable for Oral T4b Squamous Cell Cancers With Masticator Space Invasion.

Journal Article (Journal Article)

OBJECTIVES: To examine survival endpoints in patients with tumor (T)4b oral cavity squamous cell carcinoma (OCSCC) with pathologically proven masticator space invasion treated with primary surgery followed by adjuvant therapy. STUDY DESIGN: Retrospective review at an academic cancer center. METHODS: Twenty-five patients with T4b OCSCC with pathologic masticator space invasion were treated with primary surgery from May 2012 to December 2016. Only patients with ≥ 2 years follow-up from date of surgery were included. Sixteen patients received adjuvant chemoradiation. RESULTS: Median follow-up time was 39 months from date of surgery. Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival at 24 months were 44.0%, 63.2%, and 52.6%, respectively. On univariate analyses, adjuvant chemoradiation was associated with improved OS. Advanced age and prolonged length of hospital stay was associated with worse OS. CONCLUSION: For pT4b OCSCCA involving the masticator space, primary surgical resection followed by adjuvant chemoradiation demonstrates 24-month DSS of > 50% and OS of 44%. LEVEL OF EVIDENCE: 4 Laryngoscope, 131:E466-E472, 2021.

Full Text

Duke Authors

Cited Authors

  • Baddour, HM; Ochsner, MC; Patel, MR; Switchenko, JM; Beitler, JJ; Magliocca, K; Baugnon, KL; Solares, CA; Steuer, CE; El-Deiry, MW

Published Date

  • February 2021

Published In

Volume / Issue

  • 131 / 2

Start / End Page

  • E466 - E472

PubMed ID

  • 32460370

Pubmed Central ID

  • PMC7704866

Electronic International Standard Serial Number (EISSN)

  • 1531-4995

Digital Object Identifier (DOI)

  • 10.1002/lary.28725


  • eng

Conference Location

  • United States