Prostate Cancer Cell Phenotypes Remain Stable Following PDE5 Inhibition in the Clinically Relevant Range.

Journal Article (Journal Article)

Widespread cGMP-specific phosphodiesterase 5 (PDE5) inhibitor use in male reproductive health and particularly in prostate cancer patients following surgery has generated interest in how these drugs affect the ability of residual tumor cells to proliferate, migrate, and form recurrent colonies. Prostate cancer cell lines were treated with PDE5 inhibitors at clinically relevant concentrations. Proliferation, colony formation, and migration phenotypes remained stable even when cells were co-treated with a stimulator of cGMP synthesis that facilitated cGMP accumulation upon PDE5 inhibition. Surprisingly, supraclinical concentrations of PDE5 inhibitor counteracted proliferation, colony formation, and migration of prostate cancer cell models. These findings provide tumor cell-autonomous evidence in support of the field's predominant view that PDE5 inhibitors are safe adjuvant agents to promote functional recovery of normal tissue after prostatectomy, but do not rule out potential cancer-promoting effects of PDE5 inhibitors in the more complex environment of the prostate.

Full Text

Duke Authors

Cited Authors

  • Hankey, W; Sunkel, B; Yuan, F; He, H; Thomas-Ahner, JM; Chen, Z; Clinton, SK; Huang, J; Wang, Q

Published Date

  • September 2020

Published In

Volume / Issue

  • 13 / 9

Start / End Page

  • 100797 -

PubMed ID

  • 32454444

Pubmed Central ID

  • PMC7248418

International Standard Serial Number (ISSN)

  • 1936-5233

Digital Object Identifier (DOI)

  • 10.1016/j.tranon.2020.100797

Language

  • eng

Conference Location

  • United States