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Materials to Promote Recovery After Stroke.

Publication ,  Journal Article
Erning, K; Segura, T
Published in: Current opinion in biomedical engineering
June 2020

Stroke is the leading cause of long-term disability with no current treatment addressing post-stroke disability. The complex pathophysiology of stroke and the brain's limited potential for regeneration prevents sufficient endogenous repair for complete recovery. While engineered materials provide an exciting opportunity to augment endogenous repair in conjunction with other therapies that address post-stroke disability, much of the preclinical work in this arena is still in its infancy. Biomaterials can be used to enhance drug- or stem cell-sustained and targeted delivery. Moreover, materials can act as extracellular matrix-mimics and augment a pro-repair environment by addressing astrogliosis, inflammation, neurogenesis, axonal sprouting, and angiogenesis. Lastly, there is a growing need to elucidate stroke repair mechanisms to identify novel targets to inform material design for brain repair after stroke.

Duke Scholars

Published In

Current opinion in biomedical engineering

DOI

EISSN

2468-4511

ISSN

2468-4511

Publication Date

June 2020

Volume

14

Start / End Page

9 / 17

Related Subject Headings

  • 4003 Biomedical engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Erning, K., & Segura, T. (2020). Materials to Promote Recovery After Stroke. Current Opinion in Biomedical Engineering, 14, 9–17. https://doi.org/10.1016/j.cobme.2020.04.002
Erning, Kevin, and Tatiana Segura. “Materials to Promote Recovery After Stroke.Current Opinion in Biomedical Engineering 14 (June 2020): 9–17. https://doi.org/10.1016/j.cobme.2020.04.002.
Erning K, Segura T. Materials to Promote Recovery After Stroke. Current opinion in biomedical engineering. 2020 Jun;14:9–17.
Erning, Kevin, and Tatiana Segura. “Materials to Promote Recovery After Stroke.Current Opinion in Biomedical Engineering, vol. 14, June 2020, pp. 9–17. Epmc, doi:10.1016/j.cobme.2020.04.002.
Erning K, Segura T. Materials to Promote Recovery After Stroke. Current opinion in biomedical engineering. 2020 Jun;14:9–17.
Journal cover image

Published In

Current opinion in biomedical engineering

DOI

EISSN

2468-4511

ISSN

2468-4511

Publication Date

June 2020

Volume

14

Start / End Page

9 / 17

Related Subject Headings

  • 4003 Biomedical engineering