Colorectal cancer

Book Section

Inherited genetic factors play an important role in the etiology of colorectal cancer. Rare high-penetrance mutations account for a small proportion of diseases but their identification plays an important role in the clinical management of the high-risk families in which these mutations segregate. The results of most candidate gene association studies of colorectal cancer have not been replicated consistently. Many results can be considered false positives; others may represent very small effects, which will require replication in larger studies before firm conclusions can be reached. This chapter reviews recent, genome-wide association studies that have discovered many common, low-penetrance genetic variants associated with risk of colorectal cancer.

Full Text

Duke Authors

Cited Authors

  • Campbell, H; Hawken, S; Theodoratou, E; Demarsh, A; Hutchings, K; Johnson, CY; Masson, L; Sharp, L; Tait, V; Little, J

Published Date

  • May 1, 2010

Book Title

  • Human Genome Epidemiology: Building the Evidence for Using Genetic Information to Improve Health and Prevent Disease: Second Edition

International Standard Book Number 13 (ISBN-13)

  • 9780195398441

Digital Object Identifier (DOI)

  • 10.1093/acprof:oso/9780195398441.003.0013

Citation Source

  • Scopus