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Human Genome Epidemiology: Building the Evidence for Using Genetic Information to Improve Health and Prevent Disease: Second Edition

Colorectal cancer

Publication ,  Chapter
Campbell, H; Hawken, S; Theodoratou, E; Demarsh, A; Hutchings, K; Johnson, CY; Masson, L; Sharp, L; Tait, V; Little, J
May 1, 2010

Inherited genetic factors play an important role in the etiology of colorectal cancer. Rare high-penetrance mutations account for a small proportion of diseases but their identification plays an important role in the clinical management of the high-risk families in which these mutations segregate. The results of most candidate gene association studies of colorectal cancer have not been replicated consistently. Many results can be considered false positives; others may represent very small effects, which will require replication in larger studies before firm conclusions can be reached. This chapter reviews recent, genome-wide association studies that have discovered many common, low-penetrance genetic variants associated with risk of colorectal cancer.

Duke Scholars

DOI

ISBN

9780195398441

Publication Date

May 1, 2010
 

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Campbell, H., Hawken, S., Theodoratou, E., Demarsh, A., Hutchings, K., Johnson, C. Y., … Little, J. (2010). Colorectal cancer. In Human Genome Epidemiology: Building the Evidence for Using Genetic Information to Improve Health and Prevent Disease: Second Edition. https://doi.org/10.1093/acprof:oso/9780195398441.003.0013
Campbell, H., S. Hawken, E. Theodoratou, A. Demarsh, K. Hutchings, C. Y. Johnson, L. Masson, L. Sharp, V. Tait, and J. Little. “Colorectal cancer.” In Human Genome Epidemiology: Building the Evidence for Using Genetic Information to Improve Health and Prevent Disease: Second Edition, 2010. https://doi.org/10.1093/acprof:oso/9780195398441.003.0013.
Campbell H, Hawken S, Theodoratou E, Demarsh A, Hutchings K, Johnson CY, et al. Colorectal cancer. In: Human Genome Epidemiology: Building the Evidence for Using Genetic Information to Improve Health and Prevent Disease: Second Edition. 2010.
Campbell, H., et al. “Colorectal cancer.” Human Genome Epidemiology: Building the Evidence for Using Genetic Information to Improve Health and Prevent Disease: Second Edition, 2010. Scopus, doi:10.1093/acprof:oso/9780195398441.003.0013.
Campbell H, Hawken S, Theodoratou E, Demarsh A, Hutchings K, Johnson CY, Masson L, Sharp L, Tait V, Little J. Colorectal cancer. Human Genome Epidemiology: Building the Evidence for Using Genetic Information to Improve Health and Prevent Disease: Second Edition. 2010.
Journal cover image

DOI

ISBN

9780195398441

Publication Date

May 1, 2010