Illuminating the exposome with high-resolution accurate-mass mass spectrometry and nontargeted analysis
Journal Article (Review;Journal)
Exposomics seeks a comprehensive understanding of the links between human health and environmental chemical exposures. Analytical chemistry tools capable of identifying low-level organic contaminants in complex environmental samples are needed to meet the demands of exposomics studies. High-resolution accurate-mass mass spectrometry (HR/AM MS) and nontargeted analysis currently provide the only framework capable of achieving the sensitivity, specificity, and throughput required by large-scale exposomics studies. However, practical tools for the automated and reproducible structure annotation of small molecules by HR/AM MS remain underdeveloped. Herein, we review the principles of and recent advances in HR/AM MS–enabled nontargeted analysis with an emphasis on approaches to assigning chemical information to HR/AM MS data.
Full Text
Duke Authors
Cited Authors
- Getzinger, GJ; Ferguson, PL
Published Date
- June 1, 2020
Published In
Volume / Issue
- 15 /
Start / End Page
- 49 - 56
Electronic International Standard Serial Number (EISSN)
- 2468-5844
Digital Object Identifier (DOI)
- 10.1016/j.coesh.2020.05.005
Citation Source
- Scopus