Illuminating the exposome with high-resolution accurate-mass mass spectrometry and nontargeted analysis

Journal Article (Review;Journal)

Exposomics seeks a comprehensive understanding of the links between human health and environmental chemical exposures. Analytical chemistry tools capable of identifying low-level organic contaminants in complex environmental samples are needed to meet the demands of exposomics studies. High-resolution accurate-mass mass spectrometry (HR/AM MS) and nontargeted analysis currently provide the only framework capable of achieving the sensitivity, specificity, and throughput required by large-scale exposomics studies. However, practical tools for the automated and reproducible structure annotation of small molecules by HR/AM MS remain underdeveloped. Herein, we review the principles of and recent advances in HR/AM MS–enabled nontargeted analysis with an emphasis on approaches to assigning chemical information to HR/AM MS data.

Full Text

Duke Authors

Cited Authors

  • Getzinger, GJ; Ferguson, PL

Published Date

  • June 1, 2020

Published In

Volume / Issue

  • 15 /

Start / End Page

  • 49 - 56

Electronic International Standard Serial Number (EISSN)

  • 2468-5844

Digital Object Identifier (DOI)

  • 10.1016/j.coesh.2020.05.005

Citation Source

  • Scopus