The Molecular Link from Diet to Cancer Cell Metabolism.

Journal Article (Journal Article;Review)

Malignant cells remodel their metabolism to meet the demands of uncontrolled cell proliferation. These demands lead to differential requirements in energy, biosynthetic precursors, and signaling intermediates. Both genetic programs arising from oncogenic events and transcriptional programs and epigenomic events are important in providing the necessary metabolic network activity. Accumulating evidence has established that environmental factors play a major role in shaping cancer cell metabolism. For metabolism, diet and nutrition are the major environmental aspects and have emerged as key components in determining cancer cell metabolism. In this review, we discuss these emerging concepts in cancer metabolism and how diet and nutrition influence cancer cell metabolism.

Full Text

Duke Authors

Cited Authors

  • Bose, S; Allen, AE; Locasale, JW

Published Date

  • June 18, 2020

Published In

Volume / Issue

  • 78 / 6

Start / End Page

  • 1034 - 1044

PubMed ID

  • 32504556

Pubmed Central ID

  • PMC7305994

Electronic International Standard Serial Number (EISSN)

  • 1097-4164

Digital Object Identifier (DOI)

  • 10.1016/j.molcel.2020.05.018


  • eng

Conference Location

  • United States