Design, methods, and conduct of the Optic Neuritis Treatment Trial.

Journal Article (Clinical Trial;Journal Article)

The Optic Neuritis Treatment Trial (ONTT) was an investigator-initiated, multi-centered, randomized, controlled clinical trial supported by cooperative agreements and grants. It was designed to evaluate the efficacy and safety of oral prednisone or intravenous methylprednisolone followed by oral prednisone as compared with oral placebo. The primary outcome measures were contrast sensitivity and visual field; secondary measures were visual acuity and color vision. Four hundred fifty-seven patients were followed for a minimum of 6 months and a maximum of 3 years. This article describes the design and the methods used to implement the ONTT.

Full Text

Duke Authors

Cited Authors

  • Cleary, PA; Beck, RW; Anderson, MM; Kenny, DJ; Backlund, JY; Gilbert, PR

Published Date

  • April 1993

Published In

Volume / Issue

  • 14 / 2

Start / End Page

  • 123 - 142

PubMed ID

  • 8500302

International Standard Serial Number (ISSN)

  • 0197-2456

Digital Object Identifier (DOI)

  • 10.1016/0197-2456(93)90015-6


  • eng

Conference Location

  • United States