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Design, methods, and conduct of the Optic Neuritis Treatment Trial.

Publication ,  Journal Article
Cleary, PA; Beck, RW; Anderson, MM; Kenny, DJ; Backlund, JY; Gilbert, PR
Published in: Control Clin Trials
April 1993

The Optic Neuritis Treatment Trial (ONTT) was an investigator-initiated, multi-centered, randomized, controlled clinical trial supported by cooperative agreements and grants. It was designed to evaluate the efficacy and safety of oral prednisone or intravenous methylprednisolone followed by oral prednisone as compared with oral placebo. The primary outcome measures were contrast sensitivity and visual field; secondary measures were visual acuity and color vision. Four hundred fifty-seven patients were followed for a minimum of 6 months and a maximum of 3 years. This article describes the design and the methods used to implement the ONTT.

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Published In

Control Clin Trials

DOI

ISSN

0197-2456

Publication Date

April 1993

Volume

14

Issue

2

Start / End Page

123 / 142

Location

United States

Related Subject Headings

  • Vision Disorders
  • Treatment Outcome
  • Public Health
  • Prednisone
  • Placebos
  • Optic Neuritis
  • Optic Nerve
  • Middle Aged
  • Methylprednisolone
  • Male
 

Citation

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ICMJE
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Cleary, P. A., Beck, R. W., Anderson, M. M., Kenny, D. J., Backlund, J. Y., & Gilbert, P. R. (1993). Design, methods, and conduct of the Optic Neuritis Treatment Trial. Control Clin Trials, 14(2), 123–142. https://doi.org/10.1016/0197-2456(93)90015-6
Cleary, P. A., R. W. Beck, M. M. Anderson, D. J. Kenny, J. Y. Backlund, and P. R. Gilbert. “Design, methods, and conduct of the Optic Neuritis Treatment Trial.Control Clin Trials 14, no. 2 (April 1993): 123–42. https://doi.org/10.1016/0197-2456(93)90015-6.
Cleary PA, Beck RW, Anderson MM, Kenny DJ, Backlund JY, Gilbert PR. Design, methods, and conduct of the Optic Neuritis Treatment Trial. Control Clin Trials. 1993 Apr;14(2):123–42.
Cleary, P. A., et al. “Design, methods, and conduct of the Optic Neuritis Treatment Trial.Control Clin Trials, vol. 14, no. 2, Apr. 1993, pp. 123–42. Pubmed, doi:10.1016/0197-2456(93)90015-6.
Cleary PA, Beck RW, Anderson MM, Kenny DJ, Backlund JY, Gilbert PR. Design, methods, and conduct of the Optic Neuritis Treatment Trial. Control Clin Trials. 1993 Apr;14(2):123–142.
Journal cover image

Published In

Control Clin Trials

DOI

ISSN

0197-2456

Publication Date

April 1993

Volume

14

Issue

2

Start / End Page

123 / 142

Location

United States

Related Subject Headings

  • Vision Disorders
  • Treatment Outcome
  • Public Health
  • Prednisone
  • Placebos
  • Optic Neuritis
  • Optic Nerve
  • Middle Aged
  • Methylprednisolone
  • Male