RGEN Editing of RNA and DNA: The Long and Winding Road from Catalytic RNAs to CRISPR to the Clinic.
Journal Article (Journal Article)
The first clinical studies utilizing RNA-guided endonucleases (RGENs) to therapeutically edit RNA and DNA in cancer patients were recently published. These groundbreaking technological advances promise to revolutionize genetic therapy and, as I discuss, represent the culmination of decades of innovative work to engineer RGENs for such editing applications.
Full Text
Duke Authors
Cited Authors
- Sullenger, BA
Published Date
- May 28, 2020
Published In
Volume / Issue
- 181 / 5
Start / End Page
- 955 - 960
PubMed ID
- 32470403
Electronic International Standard Serial Number (EISSN)
- 1097-4172
Digital Object Identifier (DOI)
- 10.1016/j.cell.2020.04.050
Language
- eng
Conference Location
- United States