RGEN Editing of RNA and DNA: The Long and Winding Road from Catalytic RNAs to CRISPR to the Clinic.

Journal Article (Journal Article)

The first clinical studies utilizing RNA-guided endonucleases (RGENs) to therapeutically edit RNA and DNA in cancer patients were recently published. These groundbreaking technological advances promise to revolutionize genetic therapy and, as I discuss, represent the culmination of decades of innovative work to engineer RGENs for such editing applications.

Full Text

Duke Authors

Cited Authors

  • Sullenger, BA

Published Date

  • May 28, 2020

Published In

Volume / Issue

  • 181 / 5

Start / End Page

  • 955 - 960

PubMed ID

  • 32470403

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2020.04.050


  • eng

Conference Location

  • United States