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Overhead Mounted Optical Coherence Tomography in Childhood Glaucoma Evaluation.

Publication ,  Journal Article
Go, MS; Barman, NR; Kelly, MP; House, RJ; Rotruck, JC; El-Dairi, MA; Freedman, SF
Published in: J Glaucoma
September 2020

UNLABELLED: PRéCIS:: Overhead mounted spectral-domain optical coherence tomography (OCT) enables high-quality imaging of the optic nerve and macula in childhood glaucoma, and is particularly useful when standard tabletop OCT has failed or is not possible. PURPOSE: Tabletop OCT, integral to adult glaucoma management, can be limited in childhood glaucoma patients because of young age, poor cooperation, and/or technical challenges. To address these imaging difficulties, we determined the feasibility and quality of an overhead mounted unit in childhood glaucoma. Secondary aims included evaluation of peripapillary retinal nerve fiber layer (pRNFL), parafoveal total retinal thickness, and parafoveal ganglion cell complex (GCC) thickness. MATERIALS AND METHODS: Children and adults with a diagnosis of childhood glaucoma were imaged with an overhead mounted spectral-domain OCT as part of a prospective cross-sectional study. Participants had poor quality or unobtainable tabletop OCT and were scheduled for an examination under anesthesia and/or surgery as part of standard care. RESULTS: A total of 88 affected eyes in 60 of 65 (92.3%) enrolled patients (mean age, 5.9±5.9 y; range, 0.2 to 24.5) were successfully imaged. The mean image quality for analyzed scans was 22.9±6.0 dB (n=236 images). Mean values for pRNFL (80.5±31.0 µm; n=86), parafoveal total retinal thickness (301.10±39.9 µm; n=79), and parafoveal GCC thickness (96.0±21.6 µm; n=74) were calculated. CONCLUSIONS: Overhead mounted OCT allowed high-quality image acquisition and analysis in childhood glaucoma patients unable to be imaged with the tabletop counterpart, presenting an opportunity for improved clinical management and study of childhood glaucoma-related pathophysiology. pRNFL, parafoveal total retinal thickness, and parafoveal GCC thickness were decreased for affected eyes of children under 6 years of age compared with age-matched controls from a companion normative study.

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Published In

J Glaucoma

DOI

EISSN

1536-481X

Publication Date

September 2020

Volume

29

Issue

9

Start / End Page

742 / 749

Location

United States

Related Subject Headings

  • Young Adult
  • Tomography, Optical Coherence
  • Supine Position
  • Retinal Ganglion Cells
  • Prospective Studies
  • Optic Nerve
  • Ophthalmology & Optometry
  • Nerve Fibers
  • Male
  • Macula Lutea
 

Citation

APA
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ICMJE
MLA
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Go, M. S., Barman, N. R., Kelly, M. P., House, R. J., Rotruck, J. C., El-Dairi, M. A., & Freedman, S. F. (2020). Overhead Mounted Optical Coherence Tomography in Childhood Glaucoma Evaluation. J Glaucoma, 29(9), 742–749. https://doi.org/10.1097/IJG.0000000000001567
Go, Michelle S., Navajyoti R. Barman, Michael P. Kelly, Robert J. House, Jill C. Rotruck, Mays A. El-Dairi, and Sharon F. Freedman. “Overhead Mounted Optical Coherence Tomography in Childhood Glaucoma Evaluation.J Glaucoma 29, no. 9 (September 2020): 742–49. https://doi.org/10.1097/IJG.0000000000001567.
Go MS, Barman NR, Kelly MP, House RJ, Rotruck JC, El-Dairi MA, et al. Overhead Mounted Optical Coherence Tomography in Childhood Glaucoma Evaluation. J Glaucoma. 2020 Sep;29(9):742–9.
Go, Michelle S., et al. “Overhead Mounted Optical Coherence Tomography in Childhood Glaucoma Evaluation.J Glaucoma, vol. 29, no. 9, Sept. 2020, pp. 742–49. Pubmed, doi:10.1097/IJG.0000000000001567.
Go MS, Barman NR, Kelly MP, House RJ, Rotruck JC, El-Dairi MA, Freedman SF. Overhead Mounted Optical Coherence Tomography in Childhood Glaucoma Evaluation. J Glaucoma. 2020 Sep;29(9):742–749.

Published In

J Glaucoma

DOI

EISSN

1536-481X

Publication Date

September 2020

Volume

29

Issue

9

Start / End Page

742 / 749

Location

United States

Related Subject Headings

  • Young Adult
  • Tomography, Optical Coherence
  • Supine Position
  • Retinal Ganglion Cells
  • Prospective Studies
  • Optic Nerve
  • Ophthalmology & Optometry
  • Nerve Fibers
  • Male
  • Macula Lutea