Chromatin-based reprogramming of a courtship regulator by concurrent pheromone perception and hormone signaling.

Journal Article (Journal Article)

To increase fitness, animals use both internal and external states to coordinate reproductive behaviors. The molecular mechanisms underlying this coordination remain unknown. Here, we focused on pheromone-sensing Drosophila Or47b neurons, which exhibit age- and social experience-dependent increase in pheromone responses and courtship advantage in males. FruitlessM (FruM ), a master regulator of male courtship behaviors, drives the effects of social experience and age on Or47b neuron responses and function. We show that simultaneous exposure to social experience and age-specific juvenile hormone (JH) induces chromatin-based reprogramming of fruM expression in Or47b neurons. Group housing and JH signaling increase fruM expression in Or47b neurons and active chromatin marks at fruM promoter. Conversely, social isolation or loss of JH signaling decreases fruM expression and increases repressive marks around fruM promoter. Our results suggest that fruM promoter integrates coincident hormone and pheromone signals driving chromatin-based changes in expression and ultimately neuronal and behavioral plasticity.

Full Text

Duke Authors

Cited Authors

  • Zhao, S; Deanhardt, B; Barlow, GT; Schleske, PG; Rossi, AM; Volkan, PC

Published Date

  • May 2020

Published In

Volume / Issue

  • 6 / 21

Start / End Page

  • eaba6913 -

PubMed ID

  • 32494751

Pubmed Central ID

  • PMC7244261

Electronic International Standard Serial Number (EISSN)

  • 2375-2548

International Standard Serial Number (ISSN)

  • 2375-2548

Digital Object Identifier (DOI)

  • 10.1126/sciadv.aba6913

Language

  • eng