The use of ibuprofen to treat fever in COVID-19: A possible indirect association with worse outcome?

Journal Article (Journal Article)

Fever has been reported as a common symptom occurring in COVID-19 illness. Over the counter antipyretics such as ibuprofen and acetaminophen are often taken by individuals to reduce the discomfort of fever. Recently, the safety of ibuprofen in COVID-19 patients has been questioned due to anecdotal reports of worsening symptoms in previously healthy young adults. Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen. As fever may have benefit in shortening the duration of viral illness, it is plausible to hypothesize that the antipyretic efficacy of ibuprofen may be hindering the benefits of a fever response when taken during the early stages of COVID-19 illness.

Full Text

Duke Authors

Cited Authors

  • Jamerson, BD; Haryadi, TH

Published Date

  • November 2020

Published In

Volume / Issue

  • 144 /

Start / End Page

  • 109880 -

PubMed ID

  • 32505846

Pubmed Central ID

  • PMC7247463

Electronic International Standard Serial Number (EISSN)

  • 1532-2777

Digital Object Identifier (DOI)

  • 10.1016/j.mehy.2020.109880


  • eng

Conference Location

  • United States