Biomarkers in lung cancer: from early detection to novel therapeutics and decision making.

Journal Article (Journal Article)

Lung cancer remains a significant cause of mortality worldwide. While advances in therapy continue to be made, the overall prognosis for patients diagnosed with lung cancer remains poor. Historically, markers such as age, performance status and disease stage have been used to risk-stratify patients and guide therapeutic decisions. These parameters provide some useful information, but more sensitive markers are clearly needed. Molecular and genetic studies have identified several such markers, which appear to play critical roles in carcinogenesis and affect patient outcomes. This article reviews a number of biomarkers that have been identified in lung cancer, and their prognostic and predictive roles.

Full Text

Duke Authors

Cited Authors

  • Scott, A; Salgia, R

Published Date

  • December 1, 2008

Published In

Volume / Issue

  • 2 / 6

Start / End Page

  • 577 - 586

PubMed ID

  • 19802373

Pubmed Central ID

  • PMC2742385

Electronic International Standard Serial Number (EISSN)

  • 1752-0371

Digital Object Identifier (DOI)

  • 10.2217/17520363.2.6.577


  • eng

Conference Location

  • England