Signaling Pathways Controlling Microglia Chemotaxis.

Journal Article (Review;Journal Article)

Microglia are the primary resident immune cells of the central nervous system (CNS). They are the first line of defense of the brain's innate immune response against infection, injury, and diseases. Microglia respond to extracellular signals and engulf unwanted neuronal debris by phagocytosis, thereby maintaining normal cellular homeostasis in the CNS. Pathological stimuli such as neuronal injury induce transformation and activation of resting microglia with ramified morphology into a motile amoeboid form and activated microglia chemotax toward lesion site. This review outlines the current research on microglial activation and chemotaxis.

Full Text

Duke Authors

Cited Authors

  • Fan, Y; Xie, L; Chung, CY

Published Date

  • March 17, 2017

Published In

Volume / Issue

  • 40 / 3

Start / End Page

  • 163 - 168

PubMed ID

  • 28301917

Pubmed Central ID

  • PMC5386953

Electronic International Standard Serial Number (EISSN)

  • 0219-1032

International Standard Serial Number (ISSN)

  • 1016-8478

Digital Object Identifier (DOI)

  • 10.14348/molcells.2017.0011


  • eng