Signaling pathways controlling cell polarity and chemotaxis.
Publication
, Journal Article
Chung, CY; Funamoto, S; Firtel, RA
Published in: Trends in biochemical sciences
September 2001
Many important biological processes, including chemotaxis (directional cell movement up a chemoattractant gradient), require a clearly established cell polarity and the ability of the cell to respond to a directional signal. Recent advances using Dictyostelium cells and mammalian leukocytes have provided insights into the biochemical and molecular pathways that control chemotaxis. Phosphoinositide 3-kinase plays a central and possibly pivotal role in establishing and maintaining cell polarity by regulating the subcellular localization and activation of downstream effectors that are essential for regulating cell polarity and proper chemotaxis. This review outlines our present understanding of these pathways.
Published In
Trends in biochemical sciences
DOI
ISSN
0968-0004
Publication Date
September 2001
Volume
26
Issue
9
Start / End Page
557 / 566
Related Subject Headings
- Signal Transduction
- Phosphatidylinositol 3-Kinases
- Myosins
- Lipid Metabolism
- Dictyostelium
- Developmental Biology
- Cytoskeleton
- Chemotaxis
- Cell Polarity
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Chung, C. Y., Funamoto, S., & Firtel, R. A. (2001). Signaling pathways controlling cell polarity and chemotaxis. Trends in Biochemical Sciences, 26(9), 557–566. https://doi.org/10.1016/s0968-0004(01)01934-x
Chung, C. Y., S. Funamoto, and R. A. Firtel. “Signaling pathways controlling cell polarity and chemotaxis.” Trends in Biochemical Sciences 26, no. 9 (September 2001): 557–66. https://doi.org/10.1016/s0968-0004(01)01934-x.
Chung CY, Funamoto S, Firtel RA. Signaling pathways controlling cell polarity and chemotaxis. Trends in biochemical sciences. 2001 Sep;26(9):557–66.
Chung, C. Y., et al. “Signaling pathways controlling cell polarity and chemotaxis.” Trends in Biochemical Sciences, vol. 26, no. 9, Sept. 2001, pp. 557–66. Epmc, doi:10.1016/s0968-0004(01)01934-x.
Chung CY, Funamoto S, Firtel RA. Signaling pathways controlling cell polarity and chemotaxis. Trends in biochemical sciences. 2001 Sep;26(9):557–566.
Published In
Trends in biochemical sciences
DOI
ISSN
0968-0004
Publication Date
September 2001
Volume
26
Issue
9
Start / End Page
557 / 566
Related Subject Headings
- Signal Transduction
- Phosphatidylinositol 3-Kinases
- Myosins
- Lipid Metabolism
- Dictyostelium
- Developmental Biology
- Cytoskeleton
- Chemotaxis
- Cell Polarity
- Animals