Signaling pathways controlling cell polarity and chemotaxis.

Journal Article (Review;Journal Article)

Many important biological processes, including chemotaxis (directional cell movement up a chemoattractant gradient), require a clearly established cell polarity and the ability of the cell to respond to a directional signal. Recent advances using Dictyostelium cells and mammalian leukocytes have provided insights into the biochemical and molecular pathways that control chemotaxis. Phosphoinositide 3-kinase plays a central and possibly pivotal role in establishing and maintaining cell polarity by regulating the subcellular localization and activation of downstream effectors that are essential for regulating cell polarity and proper chemotaxis. This review outlines our present understanding of these pathways.

Full Text

Duke Authors

Cited Authors

  • Chung, CY; Funamoto, S; Firtel, RA

Published Date

  • September 2001

Published In

Volume / Issue

  • 26 / 9

Start / End Page

  • 557 - 566

PubMed ID

  • 11551793

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/s0968-0004(01)01934-x


  • eng