Signaling pathways at the leading edge of chemotaxing cells.
Published
Journal Article (Review)
Chemotaxis, or directed cell movement towards small molecule ligands, is a central function of many cell types and plays a key role in diverse biological processes. This review summarizes our present understanding of the signaling pathways that control the ability of cells to sense the chemoattractant gradient and respond by converting a shallow extracellular gradient into a steep intracellular gradient that leads to formation of a pseudopod in the direction of the chemoattractant gradient and contraction of the cell's posterior. The review focuses on the phosphatidylinositol 3-kinase pathway in Dictyostelium and our understanding of parallel pathways in leukocytes.
Full Text
Duke Authors
Cited Authors
- Chung, CY; Firtel, RA
Published Date
- January 2002
Published In
Volume / Issue
- 23 / 7-8
Start / End Page
- 773 - 779
PubMed ID
- 12952075
Pubmed Central ID
- 12952075
Electronic International Standard Serial Number (EISSN)
- 1573-2657
International Standard Serial Number (ISSN)
- 0142-4319
Digital Object Identifier (DOI)
- 10.1023/a:1024479728970
Language
- eng