The unique characteristics of COVID-19 coagulopathy.

Published online

Journal Article (Review)

Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC), with CAC usually showing increased D-dimer and fibrinogen levels but initially minimal abnormalities in prothrombin time and platelet count. Venous thromboembolism and arterial thrombosis are more frequent in CAC compared to SIC/DIC. Clinical and laboratory features of CAC overlap somewhat with a hemophagocytic syndrome, antiphospholipid syndrome, and thrombotic microangiopathy. We summarize the key characteristics of representative coagulopathies, discussing similarities and differences so as to define the unique character of CAC.

Full Text

Duke Authors

Cited Authors

  • Iba, T; Levy, JH; Connors, JM; Warkentin, TE; Thachil, J; Levi, M

Published Date

  • June 18, 2020

Published In

Volume / Issue

  • 24 / 1

Start / End Page

  • 360 -

PubMed ID

  • 32552865

Pubmed Central ID

  • 32552865

Electronic International Standard Serial Number (EISSN)

  • 1466-609X

Digital Object Identifier (DOI)

  • 10.1186/s13054-020-03077-0

Language

  • eng

Conference Location

  • England