Novel Therapeutic Interventions Early in the Disease Trajectory: Drug Development Beyond the Refractory Setting.

Journal Article (Journal Article)

The 2019 Accelerating Anticancer Agent Development Workshop assembled a panel of experts for an in-depth discussion session to present "novel therapeutic interventions early in the disease trajectory." The panel reviewed the limitations of evaluating investigational cancer therapeutics solely in advanced metastatic and relapsed/refractory disease settings, and recommended strategies for drug evaluation earlier in the disease course, including in the first line in combination with standard chemotherapy, and in the maintenance and neoadjuvant disease settings. Advantages of earlier drug evaluation were discussed, including expanding the population of evaluable patients, earlier response assessment via surrogate endpoints, earlier clinical benefit in the disease course, tailoring of therapies based on response, and furthering our understanding of biomarker-driven therapies.

Full Text

Duke Authors

Cited Authors

  • Hafez, N; Rugo, HS; Tempero, MA; Fox, E; Reaman, GH; Lyerly, HK; Walker, D; LoRusso, PM

Published Date

  • September 15, 2020

Published In

Volume / Issue

  • 26 / 18

Start / End Page

  • 4743 - 4747

PubMed ID

  • 32571790

Electronic International Standard Serial Number (EISSN)

  • 1557-3265

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-19-4035


  • eng

Conference Location

  • United States