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Association of Arterial Stiffness With Kidney Function Among Adults Without Chronic Kidney Disease.

Publication ,  Journal Article
Itano, S; Yano, Y; Nagasu, H; Tomiyama, H; Kanegae, H; Makino, H; Higashi, Y; Kobayashi, Y; Sogawa, Y; Satoh, M; Suzuki, K; Townsend, RR ...
Published in: Am J Hypertens
November 3, 2020

BACKGROUND: Our aims were to assess whether arterial stiffness is associated with a higher risk for kidney dysfunction among persons without chronic kidney disease (CKD). METHODS: We analyzed data from the national health checkup system in Japan; for our analyses, we selected records of individuals who completed assessments of cardio-ankle vascular index (CAVI) and kidney function from 2005 to 2016. We excluded participants who had CKD at baseline, defined as the presence of proteinuria or estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2. We compared 2 groups of CAVI measurements-the highest quartile (≧8.1) and the combined lower 3 quartiles (<8.1). We used Cox proportional hazards models to assess associations between these 2 groups and subsequent CKD events, proteinuria, eGFR <60 ml/min/1.73 m2, and rapid eGFR decline (greater than or equal to -3 ml/min/1.73 m2 per year). RESULTS: The mean age of the 24,297 included participants was 46.2 years, and 60% were female. Over a mean follow-up of 3.1 years, 1,435 CKD events occurred. In a multivariable analysis, the hazard ratios with 95% confidence intervals (CIs) for the highest vs. combined lower quartiles of CAVI measurements were 1.3 (1.1, 1.5) for CKD events, 1.3 (0.96, 1.62) for proteinuria, 1.4 (1.1, 1.7) for eGFR <60 ml/min/1.73 m2, and the odds ratio with 95% CI was 1.3 (1.1, 1.4) for rapid eGFR decline. CONCLUSIONS: Persons with CAVI measurements ≧8.1 had a higher risk for CKD events compared with their counterparts with CAVI measurements <8.1. Greater arterial stiffness among adults without CKD may be associated with kidney dysfunction.

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Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

November 3, 2020

Volume

33

Issue

11

Start / End Page

1003 / 1010

Location

United States

Related Subject Headings

  • Vascular Stiffness
  • Risk Assessment
  • Retrospective Studies
  • Renal Insufficiency, Chronic
  • Prognosis
  • Middle Aged
  • Medical Records, Problem-Oriented
  • Male
  • Kidney Function Tests
  • Kidney
 

Citation

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Itano, S., Yano, Y., Nagasu, H., Tomiyama, H., Kanegae, H., Makino, H., … Kashihara, N. (2020). Association of Arterial Stiffness With Kidney Function Among Adults Without Chronic Kidney Disease. Am J Hypertens, 33(11), 1003–1010. https://doi.org/10.1093/ajh/hpaa097
Itano, Seiji, Yuichiro Yano, Hajime Nagasu, Hirofumi Tomiyama, Hiroshi Kanegae, Hirofumi Makino, Yukihito Higashi, et al. “Association of Arterial Stiffness With Kidney Function Among Adults Without Chronic Kidney Disease.Am J Hypertens 33, no. 11 (November 3, 2020): 1003–10. https://doi.org/10.1093/ajh/hpaa097.
Itano S, Yano Y, Nagasu H, Tomiyama H, Kanegae H, Makino H, et al. Association of Arterial Stiffness With Kidney Function Among Adults Without Chronic Kidney Disease. Am J Hypertens. 2020 Nov 3;33(11):1003–10.
Itano, Seiji, et al. “Association of Arterial Stiffness With Kidney Function Among Adults Without Chronic Kidney Disease.Am J Hypertens, vol. 33, no. 11, Nov. 2020, pp. 1003–10. Pubmed, doi:10.1093/ajh/hpaa097.
Itano S, Yano Y, Nagasu H, Tomiyama H, Kanegae H, Makino H, Higashi Y, Kobayashi Y, Sogawa Y, Satoh M, Suzuki K, Townsend RR, Budoff M, Bakris G, Kashihara N. Association of Arterial Stiffness With Kidney Function Among Adults Without Chronic Kidney Disease. Am J Hypertens. 2020 Nov 3;33(11):1003–1010.
Journal cover image

Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

November 3, 2020

Volume

33

Issue

11

Start / End Page

1003 / 1010

Location

United States

Related Subject Headings

  • Vascular Stiffness
  • Risk Assessment
  • Retrospective Studies
  • Renal Insufficiency, Chronic
  • Prognosis
  • Middle Aged
  • Medical Records, Problem-Oriented
  • Male
  • Kidney Function Tests
  • Kidney