Causal inference in perioperative medicine observational research: part 2, advanced methods.

Journal Article (Journal Article;Review)

Although RCTs represent the gold standard in clinical research, most clinical questions cannot be answered using this technique, because of ethical considerations, time, and cost. The goal of observational research in clinical medicine is to gain insight into the relationship between a clinical exposure and patient outcome, in the absence of evidence from RCTs. Observational research offers additional benefit when compared with data from RCTs: the conclusions are often more generalisable to a heterogenous population, which may be of greater value to everyday clinical practice. In Part 2 of this methods series, we will introduce the reader to several advanced methods for supporting the case for causality between an exposure and outcome, including: mediation analysis, natural experiments, and joint effects methods.

Full Text

Duke Authors

Cited Authors

  • Krishnamoorthy, V; McLean, D; Ohnuma, T; Harris, SK; Wong, DJN; Wilson, M; Moonesinghe, R; Raghunathan, K

Published Date

  • September 2020

Published In

Volume / Issue

  • 125 / 3

Start / End Page

  • 398 - 405

PubMed ID

  • 32527658

Electronic International Standard Serial Number (EISSN)

  • 1471-6771

Digital Object Identifier (DOI)

  • 10.1016/j.bja.2020.03.032


  • eng

Conference Location

  • England