Limited MOMP, ATM, and their roles in carcinogenesis and cancer treatment.

Journal Article (Journal Article;Review)

Limited mitochondria outer membrane permeability (MOMP) is a novel biological process where mammalian cells initiate the intrinsic apoptosis pathway with increased mitochondrial permeability but survive. One of the major consequences of limited MOMP is apoptotic endonuclease-induced DNA double strand breaks. Recent studies indicate that these DNA double stand breaks and ensuing activation of DNA damage response factors such as ATM play important but previously underappreciated roles in carcinogenesis and tumor growth. Furthermore, novel non-canonical roles of DNA repair factors such as ATM in tumor growth and treatment are also emerging. In this review, we try to summarize recent findings on this newly revealed link between DNA double strand break repair and cell death pathways.

Full Text

Duke Authors

Cited Authors

  • Bao, X; Liu, X; Li, F; Li, C-Y

Published Date

  • 2020

Published In

Volume / Issue

  • 10 /

Start / End Page

  • 81 -

PubMed ID

  • 32566127

Pubmed Central ID

  • PMC7302000

International Standard Serial Number (ISSN)

  • 2045-3701

Digital Object Identifier (DOI)

  • 10.1186/s13578-020-00442-y


  • eng

Conference Location

  • England