Clinical value of tapentadol extended-release in painful diabetic peripheral neuropathy.

Journal Article (Journal Article;Review)

Painful diabetic peripheral neuropathy is difficult to treat, partially because the underlying mechanism of pain is not fully understood. Various treatment guidelines recommend first-line agents, such as α2-δ ligands, serotonin-norepinephrine reuptake inhibitors, and tricyclic antidepressants but combination therapy of alternative agents including opiates is often warranted. Tapentadol extended-release has a novel dual mechanism of action; it is both a mu-opioid receptor agonist and a norephinephrine reuptake inhibitor. It has been in the spotlight since it was FDA-approved specifically for the treatment of painful diabetic peripheral neuropathy in 2012. Previous reviews of tapentadol have focused on chronic pain. The purpose of this review article is to assess the efficacy and safety of tapentadol extended-release in adult populations with painful diabetic peripheral neuropathy and provide guidance for formulary decisions.

Full Text

Duke Authors

Cited Authors

  • Desai, B; Freeman, E; Huang, E; Hung, A; Knapp, E; Breunig, IM; McPherson, ML; Shaya, FT

Published Date

  • March 2014

Published In

Volume / Issue

  • 7 / 2

Start / End Page

  • 203 - 209

PubMed ID

  • 24524594

Electronic International Standard Serial Number (EISSN)

  • 1751-2441

Digital Object Identifier (DOI)

  • 10.1586/17512433.2014.889562

Language

  • eng

Conference Location

  • England