Risk of second primary cancers in individuals diagnosed with index smoking- and non-smoking- related cancers.

Journal Article (Journal Article)

PURPOSE: As the number of cancer survivors in the United States increases, quantifying the risks and burden of second primary cancers (SPCs) among cancer survivors will help develop long-term prevention and surveillance strategies. We describe the risk of developing a SPC among survivors of 10 cancer sites with the highest survival rates in the United States. METHODS: Adult patients diagnosed with an index smoking-related (urinary bladder, kidney and renal pelvis, uterine cervix, oral cavity and pharynx, and colon and rectum) and index non-smoking-related (prostate, thyroid, breast, corpus and uterus, and non-Hodgkin lymphoma) cancers were identified from Surveillance, Epidemiology, and End Results (2000-2015). SPC risks were quantified using standardized incidence ratios (SIRs) and excess absolute risks (EARs) per 10,000 person-years at risk (PYR). RESULTS: A cohort of 2,903,241 patients was identified and 259,685 (8.9%) developed SPC (7.6% of women and 10.3% of men). All index cancer sites (except prostate) were associated with a significant increase in SPC risk for women and men. Patients diagnosed with smoking-related index cancers (SIR range 1.20-2.16 for women and 1.12-1.91 for men) had a higher increased risk of SPC than patients with non-smoking-related index cancers (SIR range 1.08-1.39 for women and 1.23-1.38 for men) relative to the general population. CONCLUSION: We found that 1-in-11 cancer survivors developed a SPC. Given the increasing number of cancer survivors and the importance of SPC as a cause of cancer death, there is a need for increased screening for and prevention of SPC.

Full Text

Duke Authors

Cited Authors

  • Adjei Boakye, E; Wang, M; Sharma, A; Jenkins, WD; Osazuwa-Peters, N; Chen, B; Lee, M; Schootman, M

Published Date

  • July 2020

Published In

Volume / Issue

  • 146 / 7

Start / End Page

  • 1765 - 1779

PubMed ID

  • 32356175

Electronic International Standard Serial Number (EISSN)

  • 1432-1335

Digital Object Identifier (DOI)

  • 10.1007/s00432-020-03232-8


  • eng

Conference Location

  • Germany