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Minocycline attenuates mechanical allodynia and expression of spinal NMDA receptor 1 subunit in rat neuropathic pain model.

Publication ,  Journal Article
Pu, S; Xu, Y; Du, D; Yang, M; Zhang, X; Wu, J; Jiang, W
Published in: J Physiol Biochem
September 2013

Recent studies have indicated that minocycline, a microglia inhibitor, could potentially be used as an antinociceptive agent in pain management, although the underlying mechanisms remain elusive. In this study, we investigated the extent to which minocycline could influence pain behavior in association with the expression of the N-methyl-D-aspartic acid receptor 1 (NMDAR1) in a rat L5 spinal nerve ligation (SNL) model. We observed that the intrathecal injection of minocycline significantly attenuated mechanical allodynia in a rat SNL model from day 1 postinjection and persisted for at least 18 days. We also observed that the expression of NMDAR1 was increased in the spinal dorsal horn at 8 days after SNL, which could be partly inhibited through the intrathecal injection of minocycline. These findings suggest that the attenuation of allodynia in the SNL model following minocycline administration might be associated with the inhibited expression of NMDAR1 and, therefore, might play an important role in the minocycline-mediated antinociception.

Duke Scholars

Published In

J Physiol Biochem

DOI

EISSN

1877-8755

Publication Date

September 2013

Volume

69

Issue

3

Start / End Page

349 / 357

Location

Spain

Related Subject Headings

  • Spinal Nerves
  • Spinal Cord
  • Receptors, N-Methyl-D-Aspartate
  • Rats, Sprague-Dawley
  • Rats
  • Neuralgia
  • Minocycline
  • Male
  • Injections, Spinal
  • Hyperalgesia
 

Citation

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ICMJE
MLA
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Pu, S., Xu, Y., Du, D., Yang, M., Zhang, X., Wu, J., & Jiang, W. (2013). Minocycline attenuates mechanical allodynia and expression of spinal NMDA receptor 1 subunit in rat neuropathic pain model. J Physiol Biochem, 69(3), 349–357. https://doi.org/10.1007/s13105-012-0217-4
Pu, Shaofeng, Yongming Xu, Dongping Du, Meirong Yang, Xin Zhang, Junzhen Wu, and Wei Jiang. “Minocycline attenuates mechanical allodynia and expression of spinal NMDA receptor 1 subunit in rat neuropathic pain model.J Physiol Biochem 69, no. 3 (September 2013): 349–57. https://doi.org/10.1007/s13105-012-0217-4.
Pu S, Xu Y, Du D, Yang M, Zhang X, Wu J, et al. Minocycline attenuates mechanical allodynia and expression of spinal NMDA receptor 1 subunit in rat neuropathic pain model. J Physiol Biochem. 2013 Sep;69(3):349–57.
Pu, Shaofeng, et al. “Minocycline attenuates mechanical allodynia and expression of spinal NMDA receptor 1 subunit in rat neuropathic pain model.J Physiol Biochem, vol. 69, no. 3, Sept. 2013, pp. 349–57. Pubmed, doi:10.1007/s13105-012-0217-4.
Pu S, Xu Y, Du D, Yang M, Zhang X, Wu J, Jiang W. Minocycline attenuates mechanical allodynia and expression of spinal NMDA receptor 1 subunit in rat neuropathic pain model. J Physiol Biochem. 2013 Sep;69(3):349–357.
Journal cover image

Published In

J Physiol Biochem

DOI

EISSN

1877-8755

Publication Date

September 2013

Volume

69

Issue

3

Start / End Page

349 / 357

Location

Spain

Related Subject Headings

  • Spinal Nerves
  • Spinal Cord
  • Receptors, N-Methyl-D-Aspartate
  • Rats, Sprague-Dawley
  • Rats
  • Neuralgia
  • Minocycline
  • Male
  • Injections, Spinal
  • Hyperalgesia