Gabapentin attenuates morphine tolerance through interleukin-10.

Journal Article (Journal Article)

In this study, we examined the anti-inflammatory mechanism by which gabapentin attenuates morphine tolerance in rats. Gabapentin enhanced the antinociceptive effect of morphine and attenuated chronic morphine tolerance when administered intrathecally with morphine in naive rats. We found that a 7-day chronic intrathecal injection of morphine increased the expression of proinflammatory cytokines and decreased interleukin-10 (IL-10) levels in the rat spinal cord. These changes were minimized when gabapentin was combined with morphine. In addition, the effects of gabapentin were reversed by coadministration of the anti-IL-10 antibody. Our findings indicate that enhancement of the antinociceptive effect of morphine by gabapentin may occur through upregulation of the anti-inflammatory cytokine IL-10 and inhibition of proinflammatory cytokines in the rat spinal cord.

Full Text

Duke Authors

Cited Authors

  • Bao, Y-H; Zhou, Q-H; Chen, R; Xu, H; Zeng, L; Zhang, X; Jiang, W; Du, D

Published Date

  • January 22, 2014

Published In

Volume / Issue

  • 25 / 2

Start / End Page

  • 71 - 76

PubMed ID

  • 24247277

Electronic International Standard Serial Number (EISSN)

  • 1473-558X

Digital Object Identifier (DOI)

  • 10.1097/WNR.0b013e328363fde8


  • eng

Conference Location

  • England