The desirable donor pig to eliminate all xenoreactive antigens.

Published

Journal Article (Review)

The humoral barrier has been the limiting factor in moving xenotransplantation towards the clinic. Improvements in somatic cell nuclear transfer and genome editing, particularly CRISPR-Cas9, have made it possible to create pigs with multiple glycan xenoantigen deletions for the purposes of reducing xenoreactive antibody binding to the xenografted organ. Recent studies have also considered the aetiology and existence of antibodies directed at the swine leucocyte antigen (SLA) complex, and potential genetic engineering strategies to avoid these antibodies. Evaluation of xenoreactive antibody binding is very important for the advancement of xenotransplantation, because if patients do not have any detectable xenoreactive antibody, then it is reasonable to expect that cellular rejection and not antibody-mediated rejection (AMR) will be the next hurdle to clinical application.

Full Text

Duke Authors

Cited Authors

  • Ladowski, J; Martens, G; Estrada, J; Tector, M; Tector, J

Published Date

  • July 2019

Published In

Volume / Issue

  • 26 / 4

Start / End Page

  • e12504 -

PubMed ID

  • 30825348

Pubmed Central ID

  • 30825348

Electronic International Standard Serial Number (EISSN)

  • 1399-3089

International Standard Serial Number (ISSN)

  • 0908-665X

Digital Object Identifier (DOI)

  • 10.1111/xen.12504

Language

  • eng