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The desirable donor pig to eliminate all xenoreactive antigens.

Publication ,  Journal Article
Ladowski, J; Martens, G; Estrada, J; Tector, M; Tector, J
Published in: Xenotransplantation
July 2019

The humoral barrier has been the limiting factor in moving xenotransplantation towards the clinic. Improvements in somatic cell nuclear transfer and genome editing, particularly CRISPR-Cas9, have made it possible to create pigs with multiple glycan xenoantigen deletions for the purposes of reducing xenoreactive antibody binding to the xenografted organ. Recent studies have also considered the aetiology and existence of antibodies directed at the swine leucocyte antigen (SLA) complex, and potential genetic engineering strategies to avoid these antibodies. Evaluation of xenoreactive antibody binding is very important for the advancement of xenotransplantation, because if patients do not have any detectable xenoreactive antibody, then it is reasonable to expect that cellular rejection and not antibody-mediated rejection (AMR) will be the next hurdle to clinical application.

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Published In

Xenotransplantation

DOI

EISSN

1399-3089

ISSN

0908-665X

Publication Date

July 2019

Volume

26

Issue

4

Start / End Page

e12504

Related Subject Headings

  • Transplantation, Heterologous
  • Transplantation Immunology
  • Swine
  • Surgery
  • N-Acetylgalactosaminyltransferases
  • Mixed Function Oxygenases
  • Humans
  • Histocompatibility Antigens Class I
  • Graft Rejection
  • Genetic Engineering
 

Citation

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Ladowski, J., Martens, G., Estrada, J., Tector, M., & Tector, J. (2019). The desirable donor pig to eliminate all xenoreactive antigens. Xenotransplantation, 26(4), e12504. https://doi.org/10.1111/xen.12504
Ladowski, Joseph, Greg Martens, Jose Estrada, Matthew Tector, and Joseph Tector. “The desirable donor pig to eliminate all xenoreactive antigens.Xenotransplantation 26, no. 4 (July 2019): e12504. https://doi.org/10.1111/xen.12504.
Ladowski J, Martens G, Estrada J, Tector M, Tector J. The desirable donor pig to eliminate all xenoreactive antigens. Xenotransplantation. 2019 Jul;26(4):e12504.
Ladowski, Joseph, et al. “The desirable donor pig to eliminate all xenoreactive antigens.Xenotransplantation, vol. 26, no. 4, July 2019, p. e12504. Epmc, doi:10.1111/xen.12504.
Ladowski J, Martens G, Estrada J, Tector M, Tector J. The desirable donor pig to eliminate all xenoreactive antigens. Xenotransplantation. 2019 Jul;26(4):e12504.
Journal cover image

Published In

Xenotransplantation

DOI

EISSN

1399-3089

ISSN

0908-665X

Publication Date

July 2019

Volume

26

Issue

4

Start / End Page

e12504

Related Subject Headings

  • Transplantation, Heterologous
  • Transplantation Immunology
  • Swine
  • Surgery
  • N-Acetylgalactosaminyltransferases
  • Mixed Function Oxygenases
  • Humans
  • Histocompatibility Antigens Class I
  • Graft Rejection
  • Genetic Engineering