Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation.
Publication
, Journal Article
Dale, EA; Fields, DP; Devinney, MJ; Mitchell, GS
Published in: Exp Neurol
January 2017
Phrenic long-term facilitation (pLTF) is a form of hypoxia-induced spinal respiratory motor plasticity that requires new synthesis of brain derived neurotrophic factor (BDNF) and activation of its high-affinity receptor, tropomyosin receptor kinase B (TrkB). Since the cellular location of relevant TrkB receptors is not known, we utilized intrapleural siRNA injections to selectively knock down TrkB receptor protein within phrenic motor neurons. TrkB receptors within phrenic motor neurons are necessary for BDNF-dependent acute intermittent hypoxia-induced pLTF, demonstrating that phrenic motor neurons are a critical site of respiratory motor plasticity.
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Published In
Exp Neurol
DOI
EISSN
1090-2430
Publication Date
January 2017
Volume
287
Issue
Pt 2
Start / End Page
130 / 136
Location
United States
Related Subject Headings
- Vagotomy
- Transfection
- Time Factors
- Receptor, trkB
- Rats, Sprague-Dawley
- Rats
- RNA, Small Interfering
- Phrenic Nerve
- Neurology & Neurosurgery
- Motor Neurons
Citation
APA
Chicago
ICMJE
MLA
NLM
Dale, E. A., Fields, D. P., Devinney, M. J., & Mitchell, G. S. (2017). Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation. Exp Neurol, 287(Pt 2), 130–136. https://doi.org/10.1016/j.expneurol.2016.05.012
Dale, Erica A., Daryl P. Fields, Michael J. Devinney, and Gordon S. Mitchell. “Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation.” Exp Neurol 287, no. Pt 2 (January 2017): 130–36. https://doi.org/10.1016/j.expneurol.2016.05.012.
Dale EA, Fields DP, Devinney MJ, Mitchell GS. Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation. Exp Neurol. 2017 Jan;287(Pt 2):130–6.
Dale, Erica A., et al. “Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation.” Exp Neurol, vol. 287, no. Pt 2, Jan. 2017, pp. 130–36. Pubmed, doi:10.1016/j.expneurol.2016.05.012.
Dale EA, Fields DP, Devinney MJ, Mitchell GS. Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation. Exp Neurol. 2017 Jan;287(Pt 2):130–136.
Published In
Exp Neurol
DOI
EISSN
1090-2430
Publication Date
January 2017
Volume
287
Issue
Pt 2
Start / End Page
130 / 136
Location
United States
Related Subject Headings
- Vagotomy
- Transfection
- Time Factors
- Receptor, trkB
- Rats, Sprague-Dawley
- Rats
- RNA, Small Interfering
- Phrenic Nerve
- Neurology & Neurosurgery
- Motor Neurons