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Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation.

Publication ,  Journal Article
Dale, EA; Fields, DP; Devinney, MJ; Mitchell, GS
Published in: Exp Neurol
January 2017

Phrenic long-term facilitation (pLTF) is a form of hypoxia-induced spinal respiratory motor plasticity that requires new synthesis of brain derived neurotrophic factor (BDNF) and activation of its high-affinity receptor, tropomyosin receptor kinase B (TrkB). Since the cellular location of relevant TrkB receptors is not known, we utilized intrapleural siRNA injections to selectively knock down TrkB receptor protein within phrenic motor neurons. TrkB receptors within phrenic motor neurons are necessary for BDNF-dependent acute intermittent hypoxia-induced pLTF, demonstrating that phrenic motor neurons are a critical site of respiratory motor plasticity.

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Published In

Exp Neurol

DOI

EISSN

1090-2430

Publication Date

January 2017

Volume

287

Issue

Pt 2

Start / End Page

130 / 136

Location

United States

Related Subject Headings

  • Vagotomy
  • Transfection
  • Time Factors
  • Receptor, trkB
  • Rats, Sprague-Dawley
  • Rats
  • RNA, Small Interfering
  • Phrenic Nerve
  • Neurology & Neurosurgery
  • Motor Neurons
 

Citation

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Dale, E. A., Fields, D. P., Devinney, M. J., & Mitchell, G. S. (2017). Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation. Exp Neurol, 287(Pt 2), 130–136. https://doi.org/10.1016/j.expneurol.2016.05.012
Dale, Erica A., Daryl P. Fields, Michael J. Devinney, and Gordon S. Mitchell. “Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation.Exp Neurol 287, no. Pt 2 (January 2017): 130–36. https://doi.org/10.1016/j.expneurol.2016.05.012.
Dale EA, Fields DP, Devinney MJ, Mitchell GS. Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation. Exp Neurol. 2017 Jan;287(Pt 2):130–6.
Dale, Erica A., et al. “Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation.Exp Neurol, vol. 287, no. Pt 2, Jan. 2017, pp. 130–36. Pubmed, doi:10.1016/j.expneurol.2016.05.012.
Dale EA, Fields DP, Devinney MJ, Mitchell GS. Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation. Exp Neurol. 2017 Jan;287(Pt 2):130–136.
Journal cover image

Published In

Exp Neurol

DOI

EISSN

1090-2430

Publication Date

January 2017

Volume

287

Issue

Pt 2

Start / End Page

130 / 136

Location

United States

Related Subject Headings

  • Vagotomy
  • Transfection
  • Time Factors
  • Receptor, trkB
  • Rats, Sprague-Dawley
  • Rats
  • RNA, Small Interfering
  • Phrenic Nerve
  • Neurology & Neurosurgery
  • Motor Neurons