Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation.

Published

Journal Article

Phrenic long-term facilitation (pLTF) is a form of hypoxia-induced spinal respiratory motor plasticity that requires new synthesis of brain derived neurotrophic factor (BDNF) and activation of its high-affinity receptor, tropomyosin receptor kinase B (TrkB). Since the cellular location of relevant TrkB receptors is not known, we utilized intrapleural siRNA injections to selectively knock down TrkB receptor protein within phrenic motor neurons. TrkB receptors within phrenic motor neurons are necessary for BDNF-dependent acute intermittent hypoxia-induced pLTF, demonstrating that phrenic motor neurons are a critical site of respiratory motor plasticity.

Full Text

Duke Authors

Cited Authors

  • Dale, EA; Fields, DP; Devinney, MJ; Mitchell, GS

Published Date

  • January 2017

Published In

Volume / Issue

  • 287 / Pt 2

Start / End Page

  • 130 - 136

PubMed ID

  • 27185271

Pubmed Central ID

  • 27185271

Electronic International Standard Serial Number (EISSN)

  • 1090-2430

Digital Object Identifier (DOI)

  • 10.1016/j.expneurol.2016.05.012

Language

  • eng

Conference Location

  • United States