Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development.
Publication
, Journal Article
Omstead, AN; Kosovec, JE; Matsui, D; Martin, SA; Smith, MA; Aaron Guel, D; Kolano, J; Komatsu, Y; Habib, F; Lai, C; Christopher, K; Kelly, RJ ...
Published in: Cancer investigation
January 2018
A rat model of surgically induced reflux recapitulates the development and progression of human esophageal adenocarcinoma (EAC). In this study, reflux was induced in rats followed by postoperative endoscopy with biopsy, to diagnose and monitor disease progression. Overall, percentage agreement between visual endoscopy and gold standard histology was 95%, with disease-specific classification accuracies of 100% and 75% for Barrett's with dysplasia and EAC, respectively. Additionally, the percentage agreement for biopsy in tumors >4 mm was 75%. Thereby, establishing endoscopic evaluation as a reliable tool to assess disease progression and provide biopsies for downstream correlates in a de novo EAC model.
Duke Scholars
Published In
Cancer investigation
DOI
EISSN
1532-4192
ISSN
0735-7907
Publication Date
January 2018
Volume
36
Issue
7
Start / End Page
363 / 370
Related Subject Headings
- Tumor Burden
- Time Factors
- Reproducibility of Results
- Rats, Sprague-Dawley
- Predictive Value of Tests
- Oncology & Carcinogenesis
- Male
- Jejunostomy
- Gastroesophageal Reflux
- Esophagus
Citation
APA
Chicago
ICMJE
MLA
NLM
Omstead, A. N., Kosovec, J. E., Matsui, D., Martin, S. A., Smith, M. A., Aaron Guel, D., … Jobe, B. A. (2018). Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development. Cancer Investigation, 36(7), 363–370. https://doi.org/10.1080/07357907.2018.1499029
Omstead, Ashten N., Juliann E. Kosovec, Daisuke Matsui, Samantha A. Martin, Matthew A. Smith, D. Aaron Guel, Jenna Kolano, et al. “Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development.” Cancer Investigation 36, no. 7 (January 2018): 363–70. https://doi.org/10.1080/07357907.2018.1499029.
Omstead AN, Kosovec JE, Matsui D, Martin SA, Smith MA, Aaron Guel D, et al. Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development. Cancer investigation. 2018 Jan;36(7):363–70.
Omstead, Ashten N., et al. “Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development.” Cancer Investigation, vol. 36, no. 7, Jan. 2018, pp. 363–70. Epmc, doi:10.1080/07357907.2018.1499029.
Omstead AN, Kosovec JE, Matsui D, Martin SA, Smith MA, Aaron Guel D, Kolano J, Komatsu Y, Habib F, Lai C, Christopher K, Kelly RJ, Zaidi AH, Jobe BA. Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development. Cancer investigation. 2018 Jan;36(7):363–370.
Published In
Cancer investigation
DOI
EISSN
1532-4192
ISSN
0735-7907
Publication Date
January 2018
Volume
36
Issue
7
Start / End Page
363 / 370
Related Subject Headings
- Tumor Burden
- Time Factors
- Reproducibility of Results
- Rats, Sprague-Dawley
- Predictive Value of Tests
- Oncology & Carcinogenesis
- Male
- Jejunostomy
- Gastroesophageal Reflux
- Esophagus