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Long-Term Blood Pressure Variability in Young Adulthood and Coronary Artery Calcium and Carotid Intima-Media Thickness in Midlife: The CARDIA Study.

Publication ,  Journal Article
Nwabuo, CC; Yano, Y; Moreira, HT; Appiah, D; Vasconcellos, HD; Aghaji, QN; Viera, AJ; Rana, JS; Shah, RV; Murthy, VL; Allen, NB; Schreiner, PJ ...
Published in: Hypertension
August 2020

Recent evidence links long-term (visit-to-visit) blood pressure (BP) variability to the risk of cardiovascular disease, independent of mean BP levels. Potential associations between long-term BP variability and cardiovascular disease risk may be reflected in early life course alterations in coronary artery calcium (CAC) and carotid intima-media thickness. We evaluated 2482 CARDIA study (Coronary Artery Risk Development in Young Adults) participants (mean [SD] age at the year 20 exam [2005-2006] was 45.4 [3.6] years, 43.2% men, and 41.3% black). We included participants with BP assessments across 20-years (year 0, 2, 5, 7, 10, 15, 20 exams) and carotid intima-media thickness and CAC data at the year 20 exam. BP variability was assessed using variability independent of the mean and SD. Adjusted multivariable linear or logistic regression models (as appropriate) were used to assess associations between long-term BP variability measures and carotid intima-media thickness. and CAC (ln [CAC+1] and prevalent CAC). Long-term systolic BP variability independent of the mean (per 1 SD) was positively associated with carotid intima-media thickness (β=10 μm, SE=3, P=0.002). Similarly, long-term diastolic BP variability independent of the mean was associated with carotid intima-media thickness (β=10 μm, SE (3), P=0.001). Long-term BP variability was not associated with either ln [CAC+1] or prevalent CAC. Long-term systolic and diastolic BP variability across early adulthood was positively associated with modest adverse midlife alterations in carotid intima-media thickness but not to CAC. Our findings provide further insights into pathophysiologic mechanisms that link long-term BP variability to cardiovascular disease.

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Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

August 2020

Volume

76

Issue

2

Start / End Page

404 / 409

Location

United States

Related Subject Headings

  • Young Adult
  • Vascular Calcification
  • Middle Aged
  • Male
  • Humans
  • Heart Disease Risk Factors
  • Follow-Up Studies
  • Female
  • Coronary Vessels
  • Coronary Artery Disease
 

Citation

APA
Chicago
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Nwabuo, C. C., Yano, Y., Moreira, H. T., Appiah, D., Vasconcellos, H. D., Aghaji, Q. N., … Lima, J. A. C. (2020). Long-Term Blood Pressure Variability in Young Adulthood and Coronary Artery Calcium and Carotid Intima-Media Thickness in Midlife: The CARDIA Study. Hypertension, 76(2), 404–409. https://doi.org/10.1161/HYPERTENSIONAHA.120.15394
Nwabuo, Chike C., Yuichiro Yano, Henrique T. Moreira, Duke Appiah, Henrique D. Vasconcellos, Queen N. Aghaji, Anthony J. Viera, et al. “Long-Term Blood Pressure Variability in Young Adulthood and Coronary Artery Calcium and Carotid Intima-Media Thickness in Midlife: The CARDIA Study.Hypertension 76, no. 2 (August 2020): 404–9. https://doi.org/10.1161/HYPERTENSIONAHA.120.15394.
Nwabuo CC, Yano Y, Moreira HT, Appiah D, Vasconcellos HD, Aghaji QN, et al. Long-Term Blood Pressure Variability in Young Adulthood and Coronary Artery Calcium and Carotid Intima-Media Thickness in Midlife: The CARDIA Study. Hypertension. 2020 Aug;76(2):404–9.
Nwabuo, Chike C., et al. “Long-Term Blood Pressure Variability in Young Adulthood and Coronary Artery Calcium and Carotid Intima-Media Thickness in Midlife: The CARDIA Study.Hypertension, vol. 76, no. 2, Aug. 2020, pp. 404–09. Pubmed, doi:10.1161/HYPERTENSIONAHA.120.15394.
Nwabuo CC, Yano Y, Moreira HT, Appiah D, Vasconcellos HD, Aghaji QN, Viera AJ, Rana JS, Shah RV, Murthy VL, Allen NB, Schreiner PJ, Lloyd-Jones DM, Lima JAC. Long-Term Blood Pressure Variability in Young Adulthood and Coronary Artery Calcium and Carotid Intima-Media Thickness in Midlife: The CARDIA Study. Hypertension. 2020 Aug;76(2):404–409.

Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

August 2020

Volume

76

Issue

2

Start / End Page

404 / 409

Location

United States

Related Subject Headings

  • Young Adult
  • Vascular Calcification
  • Middle Aged
  • Male
  • Humans
  • Heart Disease Risk Factors
  • Follow-Up Studies
  • Female
  • Coronary Vessels
  • Coronary Artery Disease