Absolute lymphocyte count is a prognostic marker in Covid-19: A retrospective cohort review.

Journal Article (Journal Article)

INTRODUCTION: Prognostic factors are needed to aid clinicians in managing Covid-19, a respiratory illness. Lymphocytopenia has emerged as a simply obtained laboratory value that may correlate with prognosis. METHODS: In this article, we perform a retrospective cohort review study on patients admitted to one academic hospital for Covid-19 illness. We analyzed basic demographic, clinical, and laboratory data to understand the relationship between lymphocytopenia at the time of hospital admission and clinical outcomes. RESULTS: We discovered that lymphocyte count is lower (P = .01) and lymphocytopenia more frequent by an odds ratio of 3.40 (95% CI: 1.06-10.96; P = .04) in patients admitted to the Intensive Care Unit (ICU), a marker of disease severity, relative to those who were not. We additionally find that patients with lymphocytopenia were more likely to develop an acute kidney injury (AKI), a marker of organ failure, during admission by an odds ratio of 4.29 (95% CI: 1.35-13.57; P = .01). CONCLUSION: This evidence supports the hypothesis that lymphocytopenia can be an early, useful, and easily obtained, prognostic factor in determining the clinical course and disease severity of a patient admitted to the hospital for Covid-19.

Full Text

Duke Authors

Cited Authors

  • Wagner, J; DuPont, A; Larson, S; Cash, B; Farooq, A

Published Date

  • December 2020

Published In

Volume / Issue

  • 42 / 6

Start / End Page

  • 761 - 765

PubMed ID

  • 32779838

Pubmed Central ID

  • PMC7405282

Electronic International Standard Serial Number (EISSN)

  • 1751-553X

Digital Object Identifier (DOI)

  • 10.1111/ijlh.13288

Language

  • eng

Conference Location

  • England