Intravenous Migraine Treatment in Children and Adolescents.

Journal Article (Journal Article;Review)

PURPOSE OF REVIEW: Pediatric migraine is a common, chronic, and disabling neurological disorder in children and adolescents. Outpatient management is not always effective, and intravenous migraine management may be necessary for headache treatment in the pediatric emergency department. Most current treatment is based on retrospective evidence and there is a lack of well-designed randomized double-blinded controlled pediatric studies. Intravenous drug treatment agents including intravenous fluids, prochlorperazine, diphenhydramine, metoclopramide, dexamethasone, magnesium, valproate and propofol, and dihydroergotamine are reviewed in this paper. RECENT FINDINGS: Nineteen studies were reviewed including one prospective randomized double-blind; one single-blinded randomized; one prospective; and one open-label, randomized clinical trial. Most studies were retrospective and the quality of the studies was limited. No definite conclusions can be drawn from the studies, but appropriate prospective trials between major pediatric headache institutions will move pediatric intravenous migraine management forward.

Full Text

Duke Authors

Cited Authors

  • Werner, K; Qaiser, S; Kabbouche, M; Murphy, B; Maconochie, I; Hershey, AD

Published Date

  • July 8, 2020

Published In

Volume / Issue

  • 24 / 8

Start / End Page

  • 45 -

PubMed ID

  • 32638172

Electronic International Standard Serial Number (EISSN)

  • 1534-3081

Digital Object Identifier (DOI)

  • 10.1007/s11916-020-00867-7


  • eng

Conference Location

  • United States