Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.

Journal Article (Journal Article;Review)

Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. However, a gap remains in identifying the detailed molecular signals induced by exercise that benefits health and prevents disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this gap and generate a molecular map of exercise. Preclinical and clinical studies will examine the systemic effects of endurance and resistance exercise across a range of ages and fitness levels by molecular probing of multiple tissues before and after acute and chronic exercise. From this multi-omic and bioinformatic analysis, a molecular map of exercise will be established. Altogether, MoTrPAC will provide a public database that is expected to enhance our understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease.

Full Text

Duke Authors

Cited Authors

  • Sanford, JA; Nogiec, CD; Lindholm, ME; Adkins, JN; Amar, D; Dasari, S; Drugan, JK; Fernández, FM; Radom-Aizik, S; Schenk, S; Snyder, MP; Tracy, RP; Vanderboom, P; Trappe, S; Walsh, MJ; Molecular Transducers of Physical Activity Consortium,

Published Date

  • June 25, 2020

Published In

Volume / Issue

  • 181 / 7

Start / End Page

  • 1464 - 1474

PubMed ID

  • 32589957

Pubmed Central ID

  • PMC8800485

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2020.06.004


  • eng

Conference Location

  • United States