Red Blood Cells and Lipoproteins: Important Reservoirs and Transporters of Polyphenols and Their Metabolites.

Journal Article (Journal Article)

Dietary polyphenols are protective for chronic diseases. Their blood transport has not been well investigated. This work examines multiple classes of polyphenols and their interactions with albumin, lipoproteins, and red blood cell (RBC) compartments using four models and determines the % polyphenol in each compartment studied. The RBC alone model showed a dose-response polyphenol association with RBCs. A blood model with flavanones determined the % polyphenol that was inside RBCs and bound to the surface using a new albumin washing procedure. It was shown that RBCs can methylate flavanones. The whole blood model separated the polyphenol into four compartments with the aid of affinity chromatography. More polyphenols were found with albumin and lipoproteins (high-density lipoproteins and low-density lipoproteins) than with RBCs. In the plasma model, the polyphenols associated almost equally between lipoproteins and albumin. RBCs and lipoproteins are shown to be important reservoirs and transporters of polyphenols in blood.

Full Text

Duke Authors

Cited Authors

  • Harbi, SM; Hussien, RA; Hawasawi, I; Alshdoukhi, I; Chopra, V; Alanazi, AN; Butler, W; Koroma, R; Peters, C; Garver, DD; Vinson, JA

Published Date

  • July 2020

Published In

Volume / Issue

  • 68 / 26

Start / End Page

  • 7005 - 7013

PubMed ID

  • 32495621

Electronic International Standard Serial Number (EISSN)

  • 1520-5118

International Standard Serial Number (ISSN)

  • 0021-8561

Digital Object Identifier (DOI)

  • 10.1021/acs.jafc.0c02601


  • eng