Elevation of cardiovascular risk by non-steroidal anti-inflammatory drugs.

Journal Article (Review;Journal Article)

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently used medications. NSAIDs profoundly modify prostaglandin homeostasis through inhibition of the enzyme, cyclooxygenase (COX), especially COX-2. COX-2 inhibition is associated with adverse cardiovascular outcomes as demonstrated by recent trials using this type of drug. This review explores the latest available data, including recent, randomized, clinical trials, controversies, and pathophysiology of the adverse effects of COX-inhibition.

Full Text

Duke Authors

Cited Authors

  • Anwar, A; Anwar, IJ; Delafontaine, P

Published Date

  • November 2015

Published In

Volume / Issue

  • 25 / 8

Start / End Page

  • 726 - 735

PubMed ID

  • 25956433

Pubmed Central ID

  • 25956433

Electronic International Standard Serial Number (EISSN)

  • 1873-2615

International Standard Serial Number (ISSN)

  • 1050-1738

Digital Object Identifier (DOI)

  • 10.1016/j.tcm.2015.03.006


  • eng