Rational ligand choice extends the SABRE substrate scope.

Journal Article (Journal Article)

Here we report on chelating ligands for Signal Amplification By Reversible Exchange (SABRE) catalysts that permit hyperpolarisation on otherwise sterically hindered substrates. We demonstrate 1 H enhancements of ∼100-fold over 8.5 T thermal for 2-substituted pyridines, and smaller, yet significant enhancements for provitamin B6 and caffeine. We also show 15 N-enhancements of ∼1000-fold and 19 F-enhancements of 30-fold.

Full Text

Duke Authors

Cited Authors

  • Colell, JFP; Logan, AWJ; Zhou, Z; Lindale, JR; Laasner, R; Shchepin, RV; Chekmenev, EY; Blum, V; Warren, WS; Malcolmson, SJ; Theis, T

Published Date

  • August 2020

Published In

Volume / Issue

  • 56 / 65

Start / End Page

  • 9336 - 9339

PubMed ID

  • 32671356

Pubmed Central ID

  • PMC7443256

Electronic International Standard Serial Number (EISSN)

  • 1364-548X

International Standard Serial Number (ISSN)

  • 1359-7345

Digital Object Identifier (DOI)

  • 10.1039/d0cc01330g


  • eng