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The intersection between immunotherapy and laser interstitial thermal therapy: a multipronged future of neuro-oncology.

Publication ,  Journal Article
Srinivasan, ES; Sankey, EW; Grabowski, MM; Chongsathidkiet, P; Fecci, PE
Published in: Int J Hyperthermia
July 2020

The rise of immunotherapy (IT) in oncological treatment has greatly improved outcomes in a number of disease states. However, its use in tumors of the central nervous system (CNS) remains limited for multiple reasons related to the unique immunologic tumor microenvironment. As such, it is valuable to consider the intersection of IT with additional treatment methods that may improve access to the CNS and effectiveness of existing IT modalities. One such combination is the pairing of IT with localized hyperthermia (HT) generated through technologies such as laser interstitial thermal therapy (LITT). The wide-ranging immunomodulatory effects of localized and whole-body HT have been investigated for some time. Hyperthermia has demonstrated immunostimulatory effects at the level of tumor cells, immune cells, and the broader environment governing potential immune surveillance. A thorough understanding of these effects as well as the current and upcoming investigations of such in combination with IT is important in considering the future directions of neuro-oncology.

Duke Scholars

Published In

Int J Hyperthermia

DOI

EISSN

1464-5157

Publication Date

July 2020

Volume

37

Issue

2

Start / End Page

27 / 34

Location

England

Related Subject Headings

  • Tumor Microenvironment
  • Oncology & Carcinogenesis
  • Lasers
  • Laser Therapy
  • Immunotherapy
  • Hyperthermia, Induced
  • Humans
  • Brain Neoplasms
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
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ICMJE
MLA
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Srinivasan, E. S., Sankey, E. W., Grabowski, M. M., Chongsathidkiet, P., & Fecci, P. E. (2020). The intersection between immunotherapy and laser interstitial thermal therapy: a multipronged future of neuro-oncology. Int J Hyperthermia, 37(2), 27–34. https://doi.org/10.1080/02656736.2020.1746413
Srinivasan, Ethan S., Eric W. Sankey, Matthew M. Grabowski, Pakawat Chongsathidkiet, and Peter E. Fecci. “The intersection between immunotherapy and laser interstitial thermal therapy: a multipronged future of neuro-oncology.Int J Hyperthermia 37, no. 2 (July 2020): 27–34. https://doi.org/10.1080/02656736.2020.1746413.
Srinivasan ES, Sankey EW, Grabowski MM, Chongsathidkiet P, Fecci PE. The intersection between immunotherapy and laser interstitial thermal therapy: a multipronged future of neuro-oncology. Int J Hyperthermia. 2020 Jul;37(2):27–34.
Srinivasan, Ethan S., et al. “The intersection between immunotherapy and laser interstitial thermal therapy: a multipronged future of neuro-oncology.Int J Hyperthermia, vol. 37, no. 2, July 2020, pp. 27–34. Pubmed, doi:10.1080/02656736.2020.1746413.
Srinivasan ES, Sankey EW, Grabowski MM, Chongsathidkiet P, Fecci PE. The intersection between immunotherapy and laser interstitial thermal therapy: a multipronged future of neuro-oncology. Int J Hyperthermia. 2020 Jul;37(2):27–34.

Published In

Int J Hyperthermia

DOI

EISSN

1464-5157

Publication Date

July 2020

Volume

37

Issue

2

Start / End Page

27 / 34

Location

England

Related Subject Headings

  • Tumor Microenvironment
  • Oncology & Carcinogenesis
  • Lasers
  • Laser Therapy
  • Immunotherapy
  • Hyperthermia, Induced
  • Humans
  • Brain Neoplasms
  • 3202 Clinical sciences
  • 1103 Clinical Sciences