The origins and genomic diversity of American Civil War Era smallpox vaccine strains.
Publication
, Journal Article
Duggan, AT; Klunk, J; Porter, AF; Dhody, AN; Hicks, R; Smith, GL; Humphreys, M; McCollum, AM; Davidson, WB; Wilkins, K; Li, Y; Burke, A ...
Published in: Genome biology
July 2020
Vaccination has transformed public health, most notably including the eradication of smallpox. Despite its profound historical importance, little is known of the origins and diversity of the viruses used in smallpox vaccination. Prior to the twentieth century, the method, source and origin of smallpox vaccinations remained unstandardised and opaque. We reconstruct and analyse viral vaccine genomes associated with smallpox vaccination from historical artefacts. Significantly, we recover viral molecules through non-destructive sampling of historical materials lacking signs of biological residues. We use the authenticated ancient genomes to reveal the evolutionary relationships of smallpox vaccination viruses within the poxviruses as a whole.
Duke Scholars
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Published In
Genome biology
DOI
EISSN
1474-760X
ISSN
1474-7596
Publication Date
July 2020
Volume
21
Issue
1
Start / End Page
175
Related Subject Headings
- Vaccinia virus
- Vaccination
- Smallpox Vaccine
- Metagenome
- Humans
- History, 19th Century
- Genome, Viral
- Genetic Variation
- Bioinformatics
- American Civil War
Citation
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Chicago
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MLA
NLM
Duggan, A. T., Klunk, J., Porter, A. F., Dhody, A. N., Hicks, R., Smith, G. L., … Poinar, H. N. (2020). The origins and genomic diversity of American Civil War Era smallpox vaccine strains. Genome Biology, 21(1), 175. https://doi.org/10.1186/s13059-020-02079-z
Duggan, Ana T., Jennifer Klunk, Ashleigh F. Porter, Anna N. Dhody, Robert Hicks, Geoffrey L. Smith, Margaret Humphreys, et al. “The origins and genomic diversity of American Civil War Era smallpox vaccine strains.” Genome Biology 21, no. 1 (July 2020): 175. https://doi.org/10.1186/s13059-020-02079-z.
Duggan AT, Klunk J, Porter AF, Dhody AN, Hicks R, Smith GL, et al. The origins and genomic diversity of American Civil War Era smallpox vaccine strains. Genome biology. 2020 Jul;21(1):175.
Duggan, Ana T., et al. “The origins and genomic diversity of American Civil War Era smallpox vaccine strains.” Genome Biology, vol. 21, no. 1, July 2020, p. 175. Epmc, doi:10.1186/s13059-020-02079-z.
Duggan AT, Klunk J, Porter AF, Dhody AN, Hicks R, Smith GL, Humphreys M, McCollum AM, Davidson WB, Wilkins K, Li Y, Burke A, Polasky H, Flanders L, Poinar D, Raphenya AR, Lau TTY, Alcock B, McArthur AG, Golding GB, Holmes EC, Poinar HN. The origins and genomic diversity of American Civil War Era smallpox vaccine strains. Genome biology. 2020 Jul;21(1):175.
Published In
Genome biology
DOI
EISSN
1474-760X
ISSN
1474-7596
Publication Date
July 2020
Volume
21
Issue
1
Start / End Page
175
Related Subject Headings
- Vaccinia virus
- Vaccination
- Smallpox Vaccine
- Metagenome
- Humans
- History, 19th Century
- Genome, Viral
- Genetic Variation
- Bioinformatics
- American Civil War