Instability in Preference for Place of Death Among Patients With Symptoms of Advanced Heart Failure.

Journal Article (Journal Article)


Patient preference for place of death is an important component of advance care planning (ACP). If patients' preference for place of death changes over time, this questions the value of their documented preference. We aimed to assess the extent and correlates of change in preference for place of death over time among patients with symptoms of advanced heart failure.


We conducted a secondary analysis of data from a randomized controlled trial of a formal ACP program vs usual care.

Setting and participants

We interviewed 282 patients aged 21 years old and above with heart failure and New York Heart Association Classification III and IV symptoms in Singapore. Analytic sample included 200 patients interviewed at least twice.


We assessed factors associated with patients' preference for place of death (home/institution/no preference) and change in their preference for place of death from previous time point (change toward home death/toward an institutional death/toward no preference/no change). These included patient demographics, quality of life (Kansas City Cardiomyopathy Questionnaire), and prognostic understanding.


In our study, 66% of patients with heart failure changed their preference for place of death at least once during the study period with no consistent pattern of change. Correct prognostic understanding at the time of survey reduced the relative risk of change in preference for place of death to home (relative risk ratio 0.49, 95% confidence interval 0.32, 0.76), whereas a higher quality of life score was associated with a lower relative risk of patients changing their preferred place of death to an institution (relative risk ratio 0.99, 95% confidence interval 0.97, 1.00) relative to no change in preference.

Conclusions and implications

We provide evidence of instability in patients with heart failure preference for place of death, which suggests that ACP documents should be regularly re-evaluated.

Full Text

Duke Authors

Cited Authors

  • Malhotra, C; Bundoc, FG; Sim, D; Jaufeerally, FR; Finkelstein, EA

Published Date

  • February 2021

Published In

Volume / Issue

  • 22 / 2

Start / End Page

  • 349.e29 - 349.e34

PubMed ID

  • 32693993

Electronic International Standard Serial Number (EISSN)

  • 1538-9375

International Standard Serial Number (ISSN)

  • 1525-8610

Digital Object Identifier (DOI)

  • 10.1016/j.jamda.2020.05.030


  • eng