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Outcomes of Bilateral Cataract Surgery in Infants 7 to 24 Months of Age Using the Toddler Aphakia and Pseudophakia Treatment Study Registry.

Publication ,  Journal Article
Bothun, ED; Wilson, ME; Yen, KG; Anderson, JS; Weil, NC; Loh, AR; Morrison, D; Freedman, SF; Plager, DA; Vanderveen, DK; Traboulsi, EI ...
Published in: Ophthalmology
February 2021

PURPOSE: To evaluate outcomes of bilateral cataract surgery in children aged 7 to 24 months and compare rates of adverse events (AEs) with other Toddler Aphakia and Pseudophakia Study (TAPS) registry outcomes. DESIGN: Retrospective clinical study at 10 Infant Aphakia Treatment Study (IATS) sites. Statistical analyses comparing this cohort with previously reported TAPS registry cohorts. PARTICIPANTS: Children enrolled in the TAPS registry between 2004 and 2010. METHODS: Children underwent bilateral cataract surgery with or without intraocular lens (IOL) placement at age 7 to 24 months with 5 years of postsurgical follow-up. MAIN OUTCOME MEASURES: Visual acuity (VA), occurrence of strabismus, AEs, and reoperations. RESULTS: A total of 40 children (76 eyes) who underwent bilateral cataract surgery with primary posterior capsulectomy were identified with a median age at cataract surgery of 11 months (7-23); 68% received a primary IOL. Recurrent visual axis opacification (VAO) occurred in 7.5% and was associated only with the use of an IOL (odds ratio, 6.10; P = 0.005). Glaucoma suspect (GS) was diagnosed in 2.5%, but no child developed glaucoma. In this bilateral cohort, AEs (8/40, 20%), including glaucoma or GS and VAO, and reoperations occurred in a similar proportion to that of the published unilateral TAPS cohort. When analyzed with children aged 1 to 7 months at bilateral surgery, the incidence of AEs and glaucoma or GS correlated strongly with age at surgery (P = 0.011/0.004) and glaucoma correlated with microcornea (P = 0.040) but not with IOL insertion (P = 0.15). CONCLUSIONS: Follow-up to age 5 years after bilateral cataract surgery in children aged 7 to 24 months reveals a low rate of VAO and very rare glaucoma or GS diagnosis compared with infants with cataracts operated at < 7 months of age despite primary IOL implantation in most children in the group aged 7 to 24 months. The use of an IOL increases the risk of VAO irrespective of age at surgery.

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Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

February 2021

Volume

128

Issue

2

Start / End Page

302 / 308

Location

United States

Related Subject Headings

  • Visual Acuity
  • Vision Disorders
  • Treatment Outcome
  • Retrospective Studies
  • Registries
  • Pseudophakia
  • Ophthalmology & Optometry
  • Male
  • Lenses, Intraocular
  • Lens Implantation, Intraocular
 

Citation

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Bothun, E. D., Wilson, M. E., Yen, K. G., Anderson, J. S., Weil, N. C., Loh, A. R., … Toddler Aphakia and Pseudophakia Study, . (2021). Outcomes of Bilateral Cataract Surgery in Infants 7 to 24 Months of Age Using the Toddler Aphakia and Pseudophakia Treatment Study Registry. Ophthalmology, 128(2), 302–308. https://doi.org/10.1016/j.ophtha.2020.07.020
Bothun, Erick D., M Edward Wilson, Kimberly G. Yen, Jill S. Anderson, Natalie C. Weil, Allison R. Loh, David Morrison, et al. “Outcomes of Bilateral Cataract Surgery in Infants 7 to 24 Months of Age Using the Toddler Aphakia and Pseudophakia Treatment Study Registry.Ophthalmology 128, no. 2 (February 2021): 302–8. https://doi.org/10.1016/j.ophtha.2020.07.020.
Bothun ED, Wilson ME, Yen KG, Anderson JS, Weil NC, Loh AR, et al. Outcomes of Bilateral Cataract Surgery in Infants 7 to 24 Months of Age Using the Toddler Aphakia and Pseudophakia Treatment Study Registry. Ophthalmology. 2021 Feb;128(2):302–8.
Bothun, Erick D., et al. “Outcomes of Bilateral Cataract Surgery in Infants 7 to 24 Months of Age Using the Toddler Aphakia and Pseudophakia Treatment Study Registry.Ophthalmology, vol. 128, no. 2, Feb. 2021, pp. 302–08. Pubmed, doi:10.1016/j.ophtha.2020.07.020.
Bothun ED, Wilson ME, Yen KG, Anderson JS, Weil NC, Loh AR, Morrison D, Freedman SF, Plager DA, Vanderveen DK, Traboulsi EI, Hodge DO, Lambert SR, Toddler Aphakia and Pseudophakia Study. Outcomes of Bilateral Cataract Surgery in Infants 7 to 24 Months of Age Using the Toddler Aphakia and Pseudophakia Treatment Study Registry. Ophthalmology. 2021 Feb;128(2):302–308.
Journal cover image

Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

February 2021

Volume

128

Issue

2

Start / End Page

302 / 308

Location

United States

Related Subject Headings

  • Visual Acuity
  • Vision Disorders
  • Treatment Outcome
  • Retrospective Studies
  • Registries
  • Pseudophakia
  • Ophthalmology & Optometry
  • Male
  • Lenses, Intraocular
  • Lens Implantation, Intraocular