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Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans.

Publication ,  Journal Article
Zhang, A; Noma, K; Yan, D
Published in: G3 (Bethesda)
September 2, 2020

The regulation of gliogenesis is a fundamental process for nervous system development, as the appropriate glial number and identity is required for a functional nervous system. To investigate the molecular mechanisms involved in gliogenesis, we used C. elegans as a model and identified the function of the proneural gene lin-32/Atoh1 in gliogenesis. We found that lin-32 functions during embryonic development to negatively regulate the number of AMsh glia. The ectopic AMsh cells at least partially arise from cells originally fated to become CEPsh glia, suggesting that lin-32 is involved in the specification of specific glial subtypes. Moreover, we show that lin-32 acts in parallel with cnd-1/ NeuroD1 and ngn-1/ Neurog1 in negatively regulating an AMsh glia fate. Furthermore, expression of murine Atoh1 fully rescues lin-32 mutant phenotypes, suggesting lin-32/Atoh1 may have a conserved role in glial specification.

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Published In

G3 (Bethesda)

DOI

EISSN

2160-1836

Publication Date

September 2, 2020

Volume

10

Issue

9

Start / End Page

3271 / 3278

Location

England

Related Subject Headings

  • Transcription Factors
  • Pregnancy
  • Phenotype
  • Neuroglia
  • Neurogenesis
  • Nerve Tissue Proteins
  • Mice
  • Gene Expression Regulation, Developmental
  • Female
  • Caenorhabditis elegans Proteins
 

Citation

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Zhang, A., Noma, K., & Yan, D. (2020). Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans. G3 (Bethesda), 10(9), 3271–3278. https://doi.org/10.1534/g3.120.401547
Zhang, Albert, Kentaro Noma, and Dong Yan. “Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans.G3 (Bethesda) 10, no. 9 (September 2, 2020): 3271–78. https://doi.org/10.1534/g3.120.401547.
Zhang A, Noma K, Yan D. Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans. G3 (Bethesda). 2020 Sep 2;10(9):3271–8.
Zhang, Albert, et al. “Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans.G3 (Bethesda), vol. 10, no. 9, Sept. 2020, pp. 3271–78. Pubmed, doi:10.1534/g3.120.401547.
Zhang A, Noma K, Yan D. Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans. G3 (Bethesda). 2020 Sep 2;10(9):3271–3278.

Published In

G3 (Bethesda)

DOI

EISSN

2160-1836

Publication Date

September 2, 2020

Volume

10

Issue

9

Start / End Page

3271 / 3278

Location

England

Related Subject Headings

  • Transcription Factors
  • Pregnancy
  • Phenotype
  • Neuroglia
  • Neurogenesis
  • Nerve Tissue Proteins
  • Mice
  • Gene Expression Regulation, Developmental
  • Female
  • Caenorhabditis elegans Proteins