Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide are associated with protection against infection from household contacts of patients with cholera in Bangladesh.

Journal Article (Journal Article)

Vibrio cholerae O1 causes cholera, a dehydrating diarrheal disease. We have previously shown that V. cholerae-specific memory B cell responses develop after cholera infection, and we hypothesize that these mediate long-term protective immunity against cholera. We prospectively followed household contacts of cholera patients to determine whether the presence of circulating V. cholerae O1 antigen-specific memory B cells on enrollment was associated with protection against V. cholerae infection over a 30-day period. Two hundred thirty-six household contacts of 122 index patients with cholera were enrolled. The presence of lipopolysaccharide (LPS)-specific IgG memory B cells in peripheral blood on study entry was associated with a 68% decrease in the risk of infection in household contacts (P = 0.032). No protection was associated with cholera toxin B subunit (CtxB)-specific memory B cells or IgA memory B cells specific to LPS. These results suggest that LPS-specific IgG memory B cells may be important in protection against infection with V. cholerae O1.

Full Text

Duke Authors

Cited Authors

  • Patel, SM; Rahman, MA; Mohasin, M; Riyadh, MA; Leung, DT; Alam, MM; Chowdhury, F; Khan, AI; Weil, AA; Aktar, A; Nazim, M; LaRocque, RC; Ryan, ET; Calderwood, SB; Qadri, F; Harris, JB

Published Date

  • June 2012

Published In

Volume / Issue

  • 19 / 6

Start / End Page

  • 842 - 848

PubMed ID

  • 22518009

Pubmed Central ID

  • PMC3370438

Electronic International Standard Serial Number (EISSN)

  • 1556-679X

Digital Object Identifier (DOI)

  • 10.1128/CVI.00037-12


  • eng

Conference Location

  • United States