Skip to main content

Diagnostic accuracy of C-reactive protein for active pulmonary tuberculosis: a meta-analysis.

Publication ,  Journal Article
Yoon, C; Chaisson, LH; Patel, SM; Allen, IE; Drain, PK; Wilson, D; Cattamanchi, A
Published in: Int J Tuberc Lung Dis
September 1, 2017

SETTING: Systematic screening for active pulmonary tuberculosis (PTB) is recommended for high-risk populations, including people living with the human immunodeficiency virus (PLHIV); however, currently recommended TB screening tools are inadequate for most high-burden settings. OBJECTIVE: To determine whether C-reactive protein (CRP) possesses the necessary test characteristics to screen individuals for active PTB. DESIGN: We performed a systematic review and meta-analysis of studies evaluating the diagnostic accuracy of CRP (10 mg/l cut-off point) for culture-positive PTB. Pooled diagnostic accuracy estimates were generated using random-effects meta-analysis for out-patients and in-patients, and for pre-specified subgroups based on HIV status and test indication. RESULTS: We identified nine unique studies enrolling 1793 adults from out-patient (five studies, 1121 patients) and in-patient settings (five studies, 672 patients), 72% of whom had confirmed HIV infection. Among out-patients, CRP had high sensitivity (93%, 95%CI 88-98) and moderate specificity (60%, 95%CI 40-75) for active PTB. Specificity was lowest among in-patients (21%, 95%CI 6-52) and highest among out-patients undergoing TB screening (range 58-81%). There was no difference in summary estimates by HIV status. CONCLUSION: CRP, which is available as a simple, inexpensive and point-of-care test, can be used to screen PLHIV presenting for routine HIV/AIDS (acquired immune-deficiency syndrome) care for active TB.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Int J Tuberc Lung Dis

DOI

EISSN

1815-7920

Publication Date

September 1, 2017

Volume

21

Issue

9

Start / End Page

1013 / 1019

Location

France

Related Subject Headings

  • Tuberculosis, Pulmonary
  • Sputum
  • Sensitivity and Specificity
  • Point-of-Care Testing
  • Outpatients
  • Mycobacterium tuberculosis
  • Microbiology
  • Mass Screening
  • Humans
  • HIV Infections
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yoon, C., Chaisson, L. H., Patel, S. M., Allen, I. E., Drain, P. K., Wilson, D., & Cattamanchi, A. (2017). Diagnostic accuracy of C-reactive protein for active pulmonary tuberculosis: a meta-analysis. Int J Tuberc Lung Dis, 21(9), 1013–1019. https://doi.org/10.5588/ijtld.17.0078
Yoon, C., L. H. Chaisson, S. M. Patel, I. E. Allen, P. K. Drain, D. Wilson, and A. Cattamanchi. “Diagnostic accuracy of C-reactive protein for active pulmonary tuberculosis: a meta-analysis.Int J Tuberc Lung Dis 21, no. 9 (September 1, 2017): 1013–19. https://doi.org/10.5588/ijtld.17.0078.
Yoon C, Chaisson LH, Patel SM, Allen IE, Drain PK, Wilson D, et al. Diagnostic accuracy of C-reactive protein for active pulmonary tuberculosis: a meta-analysis. Int J Tuberc Lung Dis. 2017 Sep 1;21(9):1013–9.
Yoon, C., et al. “Diagnostic accuracy of C-reactive protein for active pulmonary tuberculosis: a meta-analysis.Int J Tuberc Lung Dis, vol. 21, no. 9, Sept. 2017, pp. 1013–19. Pubmed, doi:10.5588/ijtld.17.0078.
Yoon C, Chaisson LH, Patel SM, Allen IE, Drain PK, Wilson D, Cattamanchi A. Diagnostic accuracy of C-reactive protein for active pulmonary tuberculosis: a meta-analysis. Int J Tuberc Lung Dis. 2017 Sep 1;21(9):1013–1019.

Published In

Int J Tuberc Lung Dis

DOI

EISSN

1815-7920

Publication Date

September 1, 2017

Volume

21

Issue

9

Start / End Page

1013 / 1019

Location

France

Related Subject Headings

  • Tuberculosis, Pulmonary
  • Sputum
  • Sensitivity and Specificity
  • Point-of-Care Testing
  • Outpatients
  • Mycobacterium tuberculosis
  • Microbiology
  • Mass Screening
  • Humans
  • HIV Infections