Normal aging alters in vivo passive biomechanical response of the rat gastrocnemius-Achilles muscle-tendon unit.

Journal Article

Predisposition to Achilles tendon (AT) ruptures in middle-aged individuals may be associated with age-related changes to inherent passive biomechanical properties of the gastrocnemius-Achilles (GC-AT) muscle-tendon unit, due to known muscle-tendon structural changes in normal aging. The goal of this study was to determine whether the passive biomechanical response of the GC-AT muscle-tendon unit was altered with age in 6 young (8 months) and 6 middle-aged (24 months) F344xBN hybrid rats from the National Institute on Aging colony. Fung's quasilinear viscoelastic (QLV) model was used to determine in vivo history and time-dependent load-relaxation response of the GC-AT. Effective stiffness and modulus were also estimated using linear regression analysis. Fung's QLV revealed a significantly decreased magnitude of the relaxation response (parameter C, p=0.026) in middle-aged animals compared to young animals (0.108±0.007 vs. 0.144±0.015), with similar time-dependent viscous GC-AT properties (τ(1), τ(2)). The product of elastic parameters (A*B), which represents the initial slope of the elastic response, was significantly increased by 50% in middle-aged rats (p=0.014). Estimated GC-AT stiffness increased 28% at peak tensions in middle-aged rats (2.7±0.2 N/mm) compared to young rats (1.9±0.2 N/mm; p=0.036). While the limitations of this animal model must be considered, the changes we describe could be associated with the observation that GC-AT pathology and injury is more common in middle-aged individuals. Further studies are necessary to characterize the load-to-failure behavior of AT in middle-aged compared to young animals.

Full Text

Duke Authors

Cited Authors

  • Plate, JF; Wiggins, WF; Haubruck, P; Scott, AT; Smith, TL; Saul, KR; Mannava, S

Published Date

  • February 1, 2013

Published In

Volume / Issue

  • 46 / 3

Start / End Page

  • 450 - 455

PubMed ID

  • 23245562

Pubmed Central ID

  • 23245562

Electronic International Standard Serial Number (EISSN)

  • 1873-2380

Digital Object Identifier (DOI)

  • 10.1016/j.jbiomech.2012.11.007

Language

  • eng

Conference Location

  • United States