Botulinum Neurotoxin A injections influence stretching of the gastrocnemius muscle-tendon unit in an animal model.

Journal Article (Journal Article)

Botulinum Neurotoxin A (BoNT-A) injections have been used for the treatment of muscle contractures and spasticity. This study assessed the influence of (BoNT-A) injections on passive biomechanical properties of the muscle-tendon unit. Mousegastrocnemius muscle (GC) was injected with BoNT-A (n = 18) or normal saline (n = 18) and passive, non-destructive, in vivo load relaxation experimentation was performed to examine how the muscle-tendon unit behaves after chemical denervation with BoNT-A. Injection of BoNT-A impaired passive muscle recovery (15% vs. 35% recovery to pre-stretching baseline, p < 0.05) and decreased GC stiffness (0.531 ± 0.061 N/mm vs. 0.780 ± 0.037 N/mm, p < 0.05) compared to saline controls. The successful use of BoNT-A injections as an adjunct to physical therapy may be in part attributed to the disruption of the stretch reflex; thereby modulating in vivo passive muscle properties. However, it is also possible that BoNT-A injection may alter the structure of skeletal muscle; thus modulating the in vivo passive biomechanical properties of the muscle-tendon unit.

Full Text

Duke Authors

Cited Authors

  • Haubruck, P; Mannava, S; Plate, JF; Callahan, MF; Wiggins, WF; Schmidmaier, G; Tuohy, CJ; Saul, KR; Smith, TL

Published Date

  • August 2012

Published In

Volume / Issue

  • 4 / 8

Start / End Page

  • 605 - 619

PubMed ID

  • 23012650

Pubmed Central ID

  • PMC3446746

Electronic International Standard Serial Number (EISSN)

  • 2072-6651

Digital Object Identifier (DOI)

  • 10.3390/toxins4080605


  • eng

Conference Location

  • Switzerland