Addressing Orthostatic Hypotension in Heart Failure: Pathophysiology, Clinical Implications and Perspectives.

Journal Article (Journal Article;Review)

Heart failure (HF)is a condition at high risk for orthostatic hypotension (OH)given the large proportion of patients at an advanced age and high burden of comorbidities contributing to OH, as well as a high prevalence of medications with neurovascular and volume modulating properties. Early identification of OH in HF seems to be crucial as OH can have an impact on patient symptoms, activity level and independence, be a marker of specific pathophysiological changes or be an indicator of need for personalized treatment. OH might contribute significantly to bad enough prognosis in HF, as, besides a risk of falls and cognitive decline, it was found to be associated with cardiovascular morbidity and mortality. In this review, we aimed to incentivize the routine use of orthostatic testing in HF, as well as stimulate future research in this field, which could lead to significant advances in the treatment and outcomes.

Full Text

Duke Authors

Cited Authors

  • Soloveva, A; Fedorova, D; Villevalde, S; Zvartau, N; Mareev, Y; Sitnikova, M; Shlyakhto, E; Fudim, M

Published Date

  • August 2020

Published In

Volume / Issue

  • 13 / 4

Start / End Page

  • 549 - 569

PubMed ID

  • 32748206

Electronic International Standard Serial Number (EISSN)

  • 1937-5395

Digital Object Identifier (DOI)

  • 10.1007/s12265-020-10044-1


  • eng

Conference Location

  • United States